췌외분비기능 부전(EPI) 치료제 시장 : 질환 관리별, 치료제별, 최종사용자별, 지역별

Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market is estimated to be valued at USD 2.55 Bn in 2026 and is expected to reach USD 3.37 Bn by 2033, growing at a compound annual growth rate (CAGR) of 4.1% from 2026 to 2033.

The market is witnessing steady growth mainly driven by the rising prevalence of chronic pancreatitis and other pancreatic disorders, increasing diagnosis and treatment of EPI, growing adoption of pancreatic enzyme replacement therapy (PERT), and rising awareness regarding EPI-associated malabsorption and nutritional deficiencies.

Exocrine pancreatic insufficiency is characterized by inadequate production or delivery of pancreatic digestive enzymes, resulting in impaired digestion and nutrient absorption. The condition is commonly associated with chronic pancreatitis, cystic fibrosis, pancreatic cancer, acute pancreatitis, pancreatic surgery, and other gastrointestinal or pancreatic disorders. Treatment primarily involves pancreatic enzyme replacement therapy, supported by nutritional management and dietary modification to improve digestion, nutrient absorption, and nutritional status.

Healthcare providers are increasingly focusing on early diagnosis, optimized enzyme dosing, nutritional monitoring, and treatment adherence to improve outcomes among patients with EPI. Advances in clinical management are also encouraging more personalized PERT dosing based on meal size, fat intake, disease severity, symptoms, and nutritional response. In addition, the development of next-generation recombinant oral enzyme replacement therapies is expected to expand future treatment options and potentially reduce limitations associated with conventional porcine-derived pancreatic enzyme products.

Market Dynamics

The market is witnessing steady momentum owing to the rising burden of chronic pancreatitis, cystic fibrosis, pancreatic cancer, and other conditions associated with pancreatic exocrine dysfunction. The growing diagnosed patient population is increasing the requirement for long-term pancreatic enzyme supplementation, particularly among patients experiencing maldigestion, malabsorption, weight loss, and nutritional deficiencies.

Increasing clinical recognition and adoption of pancreatic enzyme replacement therapy is a major factor supporting market growth. PERT remains the principal therapeutic approach for EPI and is widely used to restore digestive enzyme activity and improve nutrient absorption. Increasing physician awareness, improved clinical guidelines, and greater emphasis on appropriate enzyme dosing are further strengthening treatment utilization.

The market is also benefiting from improvements in gastroenterology infrastructure and increasing access to prescription enzyme therapies. Pharmaceutical companies, gastroenterologists, pancreatologists, nutrition specialists, hospital pharmacists, and specialty pharmacies play an important role in supporting diagnosis, treatment initiation, dosing optimization, and long-term management of EPI.

At the same time, underdiagnosis, delayed diagnosis, and the high cost of long-term pancreatic enzyme replacement therapy remain key challenges. However, improving disease awareness, expanding treatment access, patient-support initiatives, and development of next-generation recombinant enzyme therapies are expected to support market expansion during the forecast period.

Key Features of the Study

• It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
• This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, market trends, regional outlook, and competitive strategies adopted by key players
• It profiles key players in the Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market based on the following parameters - company highlights, products portfolio, key highlights, financial performance, and strategies
• Key companies covered as a part of this study include AbbVie, Inc., Digestive Care, Inc., Janssen Pharmaceuticals, Inc., Anthera Pharmaceuticals, Inc., Allergan plc, AzurRx BioPharma, Inc.
• Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
• The Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
• Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market

Market Segmentation

• By Disease Management (Revenue, USD Bn, 2021-2033)
  • Nutritional Management
  • Pancreatic Enzyme Replacement Therapy (PERT)
• By Therapeutic Drugs (Revenue, USD Bn, 2021-2033)
  • Creon
  • Zenpep
  • Pancreaze
  • Ultresa
  • Viokace
  • Others
• By Region (Revenue, USD Bn, 2021-2033)
  • North America
  • U.S.
  • Canada
  • Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
  • Europe
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
  • Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • South Korea
  • ASEAN
  • Rest of Asia Pacific
  • Middle East
  • GCC
  • Israel
  • Rest of Middle East
  • Africa
  • South Africa
  • Central Africa
  • North Africa
• Key Players
  • AbbVie, Inc.
  • Digestive Care, Inc.
  • Janssen Pharmaceuticals, Inc.
  • Anthera Pharmaceuticals, Inc.
  • Allergan plc
  • AzurRx BioPharma, Inc.

Table of Contents

1. Research Objectives and Assumptions

• Research Objectives
• Assumptions
• Abbreviations

2. Market Overview

• Report Description
  • Market Definition and Scope
• Executive Summary
  • Market Snapshot, By Disease Management
  • Market Snapshot, By Therapeutic Drugs
  • Market Snapshot, By Region
• Coherent Opportunity Map (COM)

3. Market Dynamics, Regulations, and Trends Analysis

• Market Dynamics
  • Drivers
  • Restraints
  • Market Opportunities
• Impact Analysis
• Market Trends
• Key Developments
• Product Approval
• Collaboration/Merge/Acquisition
• Regulatory Landscape
• PEST Analysis
• Porter's Five Forces Analysis
• Epidemiology
• Robust Pipeline Analysis

4. Global Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market, By Disease Management, 2021 - 2033, (USD Billion)

• Introduction
  • Market Share Analysis, 2026 and 2033 (%)
  • Y-o-Y Growth Analysis, 2022- 2033
  • Segment Trends
• Nutritional Management
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Pancreatic Enzyme Replacement Therapy (PERT)
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)

5. Global Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market, By Therapeutic Drugs, 2021 - 2033, (USD Billion)

• Introduction
  • Market Share Analysis, 2026 and 2033 (%)
  • Y-o-Y Growth Analysis, 2022- 2033
  • Segment Trends
• Creon
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Zenpep
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Pancreaze
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Ultresa
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Viokace
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)
• Others
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Billion)

6. Global Exocrine Pancreatic Insufficiency (EPI) Therapeutics Market, By Region, 2021 - 2033, (USD Billion)

• Introduction
  • Market Share Analysis, By Region, 2026 and 2033 (%)
  • Y-o-Y Growth Analysis, For Regions, 2022-2033
  • Regional Trends
• North America
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • U.S.
    • Canada
• Latin America
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • Brazil
    • Mexico
    • Argentina
    • Rest of Latin America
• Europe
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • U.K.
    • Germany
    • Italy
    • France
    • Spain
    • Russia
    • Rest of Europe
• Asia Pacific
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • China
    • India
    • Japan
    • ASEAN
    • Australia
    • South Korea
    • Rest of Asia Pacific
• Middle East
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • GCC
    • Israel
    • Rest of Middle East
• Africa
  • Introduction
  • Market Size and Forecast, and Y-o-Y Growth, By Disease Management, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Therapeutic Drugs, 2021 - 2033, (USD Billion)
  • Market Size and Forecast, and Y-o-Y Growth, By Country, 2021 - 2033, (USD Billion)
    • North Africa
    • Central Africa
    • South Africa

7. Competitive Landscape

• Heat Map Analysis
• Market Share Analysis
• Company Profile
  • AbbVie, Inc.
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
  • Digestive Care, Inc.
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
  • Janssen Pharmaceuticals, Inc.
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
  • Anthera Pharmaceuticals, Inc.
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
  • Allergan plc
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
  • AzurRx BioPharma, Inc.
    • Company Highlights
    • Product Portfolio
    • Financial Performance
    • Recent Highlights
    • Market Strategies
• Analyst Views

8. Section

• References
• Research Methodology
• About Us