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시장보고서
상품코드
2082833
A형 인플루엔자 감염 : 시장 인사이트, 역학 및 예측(2036년)Influenza A Infections - Market Insight, Epidemiology, and Market Forecast - 2036 |
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DelveInsight
미국의 A형 인플루엔자 감염 시장 규모 및 전망
본 A형 인플루엔자 감염 시장 보고서에서는 현재의 치료 현황, 신약, 개별 치료법 시장 점유율, 그리고 2022년부터 2036년까지 주요 7개국(700만 명) 단위의 A형 인플루엔자 감염 시장 규모(현황 및 전망)에 대해 설명하고 있습니다. 또한, 본 보고서에서는 최적의 비즈니스 기회를 파악하고 시장의 잠재력을 평가하기 위해, 현재 A형 인플루엔자의 치료 현황 및 치료 알고리즘과 미충족 의료 수요에 대해서도 다루고 있습니다.
세계 질병 부담 증가
A형 인플루엔자는 전 세계적으로 큰 질병 부담의 원인 중 하나이며, 매년 유행이 발생하여 전 세계적으로 수백만 건의 환자와 막대한 사망자를 초래하고 있습니다. 이러한 높은 발병률과 그에 따른 의료비 부담이 예방 백신 및 항바이러스 치료에 대한 지속적인 수요를 이끌고 있습니다.
A형 인플루엔자 감염 시장에서 기회 확대
백신(mRNA 및 범용 플랫폼 등)의 혁신, 신규 항바이러스제, 진단법의 개선에 더해, 코로나19 이후 예방접종 활동의 확대가 시장 기회 확대를 뒷받침하고 있습니다. 또한, 세계보건기구(WHO) 등 기관들의 전 세계적인 관심 증가와 생명공학 분야에 대한 투자 확대가 시장 성장과 팬데믹 대비를 가속화하고 있습니다.
A형 인플루엔자의 개요와 진단
A형 인플루엔자 바이러스는 바이러스 표면에 있는 두 가지 단백질, 즉 헤마글루티닌(H)과 노이라미니다제(N)에 따라 아형으로 분류됩니다. 헤마글루티닌에는 18가지의 서로 다른 아형이 있으며, 뉴라미니다제에는 11가지의 아형이 있습니다(각각 H1부터 H18, N1부터 N11). 자연계에서는 주로 야생조류에서 130종 이상의 인플루엔자 A형 아형 조합이 확인되었으나, 잠재적으로는 이보다 더 많은 조합이 존재할 가능성이 있습니다. A형 인플루엔자의 경우, 때때로 '항원 변이'가 발생합니다. 이는 바이러스 표면 항원(HA 및 NA)에 현저한 변화가 발생하여 새로운 아형이 출현하는 현상으로, 종종 감염률 및 사망률 증가를 동반하는 전 세계적인 대유행을 초래합니다.
A형 인플루엔자를 포함한 인플루엔자 바이러스의 진단은 일반적으로 임상 증상을 바탕으로 이루어지며, 검사를 통해 확정됩니다. 의료 종사자들은 호흡기 검체 내의 바이러스 항원을 검출하여 몇 분 이내에 결과를 확인할 수 있는 ‘인플루엔자 신속 진단 검사(RIDT)’를 자주 이용하고 있습니다. 특히 유행 시기나 중증 환자의 경우, 역전사 중합효소 연쇄반응(RT-PCR) 등 보다 정확한 방법을 사용하여 바이러스의 유형이나 아형을 확인합니다. 상황에 따라 바이러스 배양이나 면역형광검사가 실시되기도 하지만, 이러한 검사들은 더 많은 시간이 소요됩니다. 적절한 치료를 실시하고 바이러스의 확산을 막기 위해서는 조기 및 정확한 진단이 중요합니다. 신속 분자 검사는 상기도 검체를 대상으로 하는 새로운 유형의 분자 인플루엔자 진단 검사로, 높은 민감도와 특이도를 갖추고 있습니다. 미국에서는 FDA 승인을 받은 2종의 신속 분자 검사가 이용 가능합니다. 신속 분자 검사에서는 약 20분 만에 결과를 확인할 수 있습니다.
A형 인플루엔자 치료의 현황
치료법은 질환의 중증도에 따라 다릅니다. 합병증이 없는 계절성 독감 환자에게는 대증 요법이 권장되며, 바이러스의 확산을 막기 위해 자택에서 대기하도록 권고받습니다. 치료는 발열 등 인플루엔자 증상을 완화하는 데 중점을 둡니다. 환자는 자신의 상태를 관찰하여 악화 징후가 없는지 확인하고, 필요에 따라 의료기관을 방문해야 합니다. 고위험군 환자에게는 증상이 나타난 후 48시간 이내에 오셀타미비르 등의 항바이러스제를 투여해야 합니다. 폐렴이나 패혈증과 같은 중증 환자의 경우, 즉시 항바이러스 치료를 실시해야 합니다. 노이라미니다제 억제제는 최소 5일간 처방해야 하며, 코르티코스테로이드는 필요한 경우에만 사용해야 합니다. 백신 접종은 여전히 가장 효과적인 예방법이며, 면역력을 유지하기 위해 매년 접종하는 것이 권장됩니다.
A형 인플루엔자의 역학 분석 및 예측에 관한 주요 연구 결과
A형 인플루엔자 백신은 가장 널리 유행하는 균주에 대한 예방에 있어 여전히 필수적이며, 전 세계 감시 데이터를 바탕으로 매년 업데이트되고 있습니다. 'FLUZONE'(불활성화 인플루엔자 백신)이나 'FluMist'(약독 생인플루엔자 백신) 등의 백신은 감염 예방 및 질병의 중증도 완화에 도움이 되는 면역 반응을 유도합니다. 최근의 진전으로는 모더나(Moderna, mRNA-1010) 등이 개발한 차세대 mRNA 기반 백신을 들 수 있습니다. 이들은 현재 규제 당국의 심사를 받고 있으나, 기존 플랫폼에 비해 주식 시장에 더 신속하게 적용될 가능성이 있습니다. 이러한 백신들은 계절성 유행의 억제 및 고령자나 기저질환이 있는 사람들을 포함한 고위험군의 보호에 있어 계속해서 중요한 역할을 하고 있습니다.
항바이러스 요법은 특히 증상의 중증도나 지속 기간을 완화하기 위해 조기에 투여될 경우, 인플루엔자 관리의 중요한 요소로 자리 잡고 있습니다. 현재 권장되는 항바이러스제에는 오셀타미비르 인산염(타미플루), 자나미비르 흡입용 분말(레렌자), 페라미비르 주사제(라피바브), 그리고 발록사비르 말보실(XOFLUZA) 등이 있습니다. 이 중 ‘XOFLUZA’는 1회 투여형 경구 제제라는 점과 노출 후 예방 목적으로의 사용이 확대되고 있다는 점에서 주목을 받고 있습니다. 이러한 선택지가 있음에도 불구하고, 최근 몇 년간 주요한 새로운 항바이러스제 계열이 도입되지 않아, 인플루엔자 치료 분야에서 여전히 충족되지 않은 의료적 요구가 존재한다는 사실이 부각되고 있습니다.
A형 인플루엔자에 대한 이해와 관리 면에서는 진전이 보이고 있지만, 항원 드리프트나 시프트와 같은 문제들이 백신의 유효성에 지속적으로 영향을 미치며, 계절성 유행의 위험을 높이고 있습니다. 개발 파이프라인에는 Cocrystal Pharma사의 CC-42344나 Moderna사의 mRNA-1010 등의 임상시험 후보가 포함되어 있지만, 그 대부분은 개발 초기부터 중기 단계에 머물러 있어 항바이러스 치료 분야에서는 단기적으로 큰 변화가 기대되지 않습니다. 2024년 기준, A형 인플루엔자 감염 시장 규모는 EU4 및 영국(독일, 프랑스, 이탈리아, 영국, 스페인)과 일본에 비해 미국이 가장 큰 비중을 차지했습니다.
EU4 및 영국 중에서 2024년 A형 인플루엔자 감염 시장 현황을 살펴보면, 독일이 가장 큰 시장 규모를 기록한 반면, 스페인은 가장 작은 시장 규모를 기록했습니다. A형 인플루엔자의 향후 전망과 관련하여, 개발 파이프라인에서 다양한 치료 옵션이 평가되고 있습니다. 이러한 치료법들의 출시가 예상에 따라, 향후 몇 년 동안 A형 인플루엔자 감염 시장 규모는 확대될 것으로 전망됩니다.
Influenza A Market Size and Forecast in the United States
DelveInsight's "Influenza A - Market Insights, Epidemiology, and Market Forecast - 2036" report delivers an in-depth understanding of influenza A, historical and forecasted epidemiology as well as influenza A market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
The influenza A market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM influenza A market size from 2022 to 2036. The report also covers current influenza A treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.
Key Factors Driving the Influenza A Market
Rise Global Disease Burden
Influenza A contributes to a substantial global disease burden, with annual epidemics resulting in millions of cases and significant mortality worldwide. This high incidence and associated healthcare burden drive sustained demand for preventive vaccines and antiviral therapies.
Rising opportunities in Influenza A
Driven by innovations in vaccines (e.g., mRNA and universal platforms), novel antivirals, and improved diagnostics, alongside expanded immunization efforts post-COVID-19. Additionally, increasing global focus from organizations like the World Health Organization and growing biotech investments are accelerating market growth and pandemic preparedness.
Emerging Influenza A Competitive Landscape
Some of the Influenza A drugs in clinical trials include CD388 (Merck), GSK4382276A (GlaxoSmithKline), CC-42344 (Cocrystal Pharma) and others.
Influenza A Overview and Diagnosis
Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: hemagglutinin (H) and neuraminidase (N). There are 18 different hemagglutinin subtypes and 11 neuraminidase subtypes (H1 through H18 and N1 through N11, respectively). While more than 130 influenza A subtype combinations have been identified in nature, primarily from wild birds, there are potentially many more influenza A subtype combinations. Occasionally with influenza A, an antigenic shift occurs. This is a significant change in the virus surface antigens (HA and NA), which leads to the emergence of a new subtype, often resulting in a global pandemic with increased morbidity and mortality.
Diagnosis of influenza virus, including Influenza A, is typically based on clinical symptoms and can be confirmed with laboratory tests. Healthcare providers often use Rapid Influenza Diagnostic Tests (RIDTs), which detect viral antigens in respiratory samples and provide results within minutes. More accurate methods, such as Reverse Transcription-Polymerase Chain Reaction (RT-PCR), are used to confirm the virus type and subtype, especially during outbreaks or severe cases. In some situations, viral culture or immunofluorescence tests may also be performed, though these take longer. Early and accurate diagnosis is important for proper treatment and to help prevent the spread of the virus. Rapid molecular assays are a new kind of molecular influenza diagnostic test for upper respiratory tract specimens with high sensitivity and specificity. Two FDA-cleared rapid molecular assays are available in the United States. Rapid molecular assays can provide results in approximately 20 min.
Influenza A Treatment Landscape
The treatment depends on the severity of diseases. For patients with uncomplicated seasonal influenza, symptomatic treatment is recommended, with advice to stay home to prevent spreading the virus. Treatment focuses on relieving symptoms of influenza, such as fever. Patients should monitor themselves to detect if their condition deteriorates and seek medical attention. High-risk patients should receive antiviral medications, such as oseltamivir, within 48 hours of symptom onset. Severe cases, including pneumonia or sepsis, require immediate antiviral treatment. Neuraminidase inhibitors should be prescribed for at least 5 days, and corticosteroids should only be used if necessary. Vaccination remains the most effective prevention method, with annual doses recommended to maintain immunity.
Influenza A Unmet Needs
The section "unmet needs of influenza A" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.
Key Findings from Influenza A Epidemiological Analysis and Forecast
Influenza A Drug Analysis & Competitive Landscape
The influenza A drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline across Phase I/II-II clinical trials. It covers mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, strategic partnerships upcoming Key catalyst for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the Influenza A treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the Influenza A therapeutics market.
Approved Therapies for Influenza A
XOFLUZA (baloxavir marboxil): Roche and Shionogi
XOFLUZA is a first-in-class, single-dose oral medicine with an innovative proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. XOFLUZA is the first in a class of antivirals designed to inhibit the cap-dependent endonuclease protein, which is essential for viral replication.
In October 2018, Roche announced that the US FDA had approved XOFLUZA for the treatment of acute, uncomplicated influenza, or flu, in people 12 years of age and older. In August 2022, Genentech announced that the US FDA approved a supplemental New Drug Application for XOFLUZA to treat acute, uncomplicated influenza in healthy children aged 5 to under 12, showing symptoms for no more than 48 hours. The FDA also approved its use for preventing influenza in the same age group after exposure to an infected person. XOFLUZA is approved in the EU for the treatment of uncomplicated influenza and for post-exposure prophylaxis of influenza in children aged one year and above, and in adolescents and adults.
Influenza A Pipeline Analysis
CC-42344: Cocrystal Pharma
CC-42344, a novel PB2 inhibitor, was selected as a preclinical lead as an oral or inhaled treatment of pandemic and seasonal influenza A. This candidate binds to a highly conserved PB2 site of influenza polymerase complex (PB1: PB2: PA) and exhibits a novel mechanism of action. CC-42344 showed excellent in vitro antiviral activity against influenza A strains, including avian pandemic strains and TAMIFLU and XOFLUZA resistant strains, and has favorable pharmacokinetic and drug resistance profiles. The company had received authorization from the United Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA) to conduct a Phase IIa human challenge study with CC-42344.
Influenza A Key Players, Market Leaders and Emerging Companies
Influenza A Drug Updates
Influenza A vaccines remain essential in protecting against the most prevalent circulating strains, with annual updates guided by global surveillance data. Vaccines such as FLUZONE (inactivated influenza vaccine) and FluMist (live attenuated influenza vaccine) stimulate immune responses that help prevent infection or reduce disease severity. Recent advancements include the development of next-generation mRNA-based vaccines, such as those by Moderna (mRNA-1010), which are currently under regulatory review and offer the potential for faster strain adaptation compared to traditional platforms. These vaccines continue to play a critical role in mitigating seasonal outbreaks and protecting high-risk populations, including the elderly and individuals with comorbidities.
Antiviral therapies remain a key component of influenza management, particularly when administered early to reduce symptom severity and duration. Currently recommended antivirals include oseltamivir phosphate (TAMIFLU), zanamivir inhalation powder (RELENZA), peramivir injection (RAPIVAB), and baloxavir marboxil (XOFLUZA). Among these, XOFLUZA has gained increased attention due to its single-dose oral regimen and expanding use in post-exposure prophylaxis settings. Despite these options, no major new antiviral classes have been introduced in recent years, highlighting a continued unmet need in influenza treatment.
Although progress has been made in understanding and managing Influenza A, challenges such as antigenic drift and shift continue to impact vaccine effectiveness and increase the risk of seasonal outbreaks. The development pipeline includes investigational candidates such as CC-42344 by Cocrystal Pharma and mRNA-1010 by Moderna; however, most remain in early to mid-stage development, with limited near-term disruption expected in the antiviral treatment landscape.The US accounted for the largest market size of influenza A, in comparison to EU4 and the UK (Germany, France, Italy, the UK, and Spain) and Japan in 2024.
Among the EU4 and the UK, Germany had the highest market size, while Spain had the lowest market size for influenza A in 2024.The emerging landscape for influenza A is having many management options that are being evaluated in the pipeline. The expected launch of these therapies is expected to increase the market size of influenza A in the coming years.
Drug Class/Insights into Leading Emerging and Marketed Therapies in Influenza A (2026-2036 Forecast)
PB2 inhibitor: Inhibitors targeting the PB2 subunit of the influenza A virus RNA-dependent RNA polymerase have been developed to disrupt the viral replication cycle. The PB2 protein plays an essential role in the cap-snatching mechanism, wherein the virus cleaves 5'-capped primers from host pre-mRNA to initiate the synthesis of viral mRNA. PB2 inhibitors function by binding to the cap-binding domain of the subunit, thereby preventing the acquisition of host-derived RNA primers and effectively halting viral transcription.
Influenza A Drug Uptake
This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2022-2036. The landscape of influenza A treatment has experienced a profound transformation with the uptake of novel drugs. These innovative therapies are redefining standards of care. Furthermore, the increased uptake of these transformative drugs is a testament to the unwavering dedication of physicians, professionals, and the entire healthcare community in their tireless pursuit of advancing disease care. This momentous shift in treatment paradigms is a testament to the power of research, collaboration, and human resilience.
Detailed insights of emerging therapies' drug uptake is included in the report
Market Access and Reimbursement of Approved therapies in Influenza A
Globally, influenza A patient families spend an essential proportion of their household income on influenza A care. Influenza A patients have to face economic burden alone without any healthcare coverage or proper reimbursement policies.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Reimbursement is a crucial factor that affects the drug's access to the market. Often, the decision to reimburse comes down to the price of the drug relative to the benefit it produces in treated patients. To reduce the healthcare burden of these high-cost therapies, many payment models are being considered by payers and other industry insiders.
NOTE: Further Details are provided in the final report....
Influenza A Therapies Price Scenario & Trends
Pricing and analogue assessment of Influenza A therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.
Industry Experts and Physician Views for Influenza A
To keep up with Influenza A market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on the Influenza A emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in Influenza and others.
DelveInsight's analysts connected with 15+ KOLs to gather insights at country level. Centers such as the Medicine at Harvard Medical School in the US, Oxford University in the UK, University of California, San Francisco, and University of Heidelberg in Germany, etc. were contacted.Their opinion helps understand and validate current and emerging Influenza A therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in Influenza A.
Qualitative Analysis: SWOT and Conjoint Analysis
We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.
In the SWOT analysis of Influenza A , strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.
Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are majorly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Insights