핵산 기반 의약품 시장 : 약물 유형, 분자 유형, 투여 경로, 치료 분야, 최종사용자별 - 세계 예측(2025-2030년)

The Nucleic Acid-Based Drugs Market was valued at USD 33.37 billion in 2024 and is projected to grow to USD 37.76 billion in 2025, with a CAGR of 13.39%, reaching USD 70.95 billion by 2030.

The landscape of nucleic acid-based drugs has evolved substantially over the past decade, driven by significant scientific breakthroughs, innovative clinical strategies, and a deepening understanding of molecular biology. This market has transformed from a niche area of research to a dynamic field that is redefining therapeutic interventions for complex diseases. Pioneering discoveries in gene expression modulation have shaped the discovery and development of various drug types, such as those that target RNA and DNA functionality, leading to unprecedented therapeutic possibilities. The integration of novel delivery mechanisms, enhanced synthesis techniques, and robust regulatory support has further established this sector as a cornerstone for future medical treatments.

The ongoing convergence of biotechnology and digital advancements has not only accelerated research but has also paved the way for rapid clinical translations. Stakeholders across academia, pharmaceutical companies, and clinical research institutes are leveraging these developments to address unmet medical needs. This blend of breakthrough science and innovative technology positions the market to deliver substantial improvements in patient outcomes and therapeutic precision. As such, the ongoing evolution of the nucleic acid-based drugs market reflects a robust and resilient ecosystem capable of surmounting challenges and seizing opportunities in a rapidly changing global healthcare environment.

Transformative Shifts in the Nucleic Acid-Based Drugs Market

Recent years have witnessed transformative shifts in the nucleic acid-based drugs market that are redefining therapeutic modalities and market dynamics. A surge in clinical trial activity has underscored the importance of precision medicine, leading to early-stage compounds progressing more rapidly through clinical pipelines. Breakthrough innovations in delivery systems have significantly improved the bioavailability and targeting efficacy of nucleic acid therapeutics, thereby mitigating traditional challenges associated with stability and cellular uptake.

Advances in genomic editing, coupled with an enhanced understanding of RNA biology, have provided the framework for next-generation treatments that are both versatile and patient-specific. Emerging business models and collaborative frameworks have enabled cross-sector partnerships, where academia, research organizations, and industry leaders share insights and resources. This collaborative spirit has been essential in integrating novel drug candidates into streamlined regulatory pathways and expedited market accesses.

The impact of these shifts is far-reaching, inspiring a wave of investments that not only accelerate market growth but also foster technological innovation. With enhanced computational modeling and state-of-the-art biomanufacturing techniques, stakeholders now enjoy greater flexibility, design precision, and operational efficiency in drug development. The transformative shifts in this market are creating an environment where continuous improvement and breakthrough research are the foundations for long-term success.

Key Segmentation Insights Driving Strategy

The multifaceted nature of the nucleic acid-based drugs market is highlighted by a diverse segmentation strategy that provides critical insights into underlying trends. From a drug type perspective, the market encompasses an array of therapeutic modalities including Antisense Oligonucleotides, DNA/RNA Aptamers, mRNA-Based Therapeutics, Nucleoside Analogs, and RNA Interference (RNAi) Therapeutics. In particular, RNAi Therapeutics are examined in greater depth by further classifying the category into MicroRNA (MiRNA), Short Hairpin RNA (ShRNA), and Short Interfering RNA (SiRNA), each with distinctive mechanisms of action that pave the way for targeted therapy solutions.

In addition, the segmentation based on molecule type divides the market into Large Molecules and Small Molecules, with each segment demonstrating unique market dynamics and commercial potentials. The route of administration segmentation provides valuable insights into patient compliance and therapeutic outcomes, with modalities ranging from Inhalation and Intramuscular to Intravenous, Oral, and Subcutaneous methods that reflect the complexity of patient needs and clinical practices.

Examining therapeutic areas, the market is analyzed across Cardiovascular Diseases, Infectious Diseases, Metabolic Disorders, Neurological Disorders, Oncology, and Rare Diseases. Further refinement in this area sees the Infectious Diseases category dissected into Bacterial Infections, Fungal Infections, and Viral Infections, while Oncology is analyzed through the lens of Hematologic Malignancies and Solid Tumors. Complementing this, market end-user segmentation evaluates the impact on Academic & Research Institutes, Contract Research Organizations, Hospitals & Clinics, and Pharmaceutical & Biotechnology Companies. This intricate segmentation not only informs strategic decision-making, but also provides a granular view of how patient demographics, therapy types, and regional variations coalesce to shape market trajectory.

Based on Drug Type, market is studied across Antisense Oligonucleotides, DNA/RNA Aptamers, mRNA-Based Therapeutics, Nucleoside Analogs, and RNA Interference (RNAi) Therapeutics. The RNA Interference (RNAi) Therapeutics is further studied across MicroRNA (MiRNA), Short Hairpin RNA (ShRNA), and Short Interfering RNA (SiRNA).

Based on Molecule Type, market is studied across Large Molecule and Small Molecule.

Based on Route of Administration, market is studied across Inhalation, Intramuscular, Intravenous, Oral, and Subcutaneous.

Based on Therapeutic Area, market is studied across Cardiovascular Diseases, Infectious Diseases, Metabolic Disorders, Neurological Disorders, Oncology, and Rare Diseases. The Infectious Diseases is further studied across Bacterial Infections, Fungal Infections, and Viral Infections. The Oncology is further studied across Hematologic Malignancies and Solid Tumors.

Based on End-User, market is studied across Academic & Research Institutes, Contract Research Organizations, Hospitals & Clinics, and Pharmaceutical & Biotechnology Companies.

Global Regional Dynamics in Nucleic Acid-Based Drugs

Assessing the regional landscape of the nucleic acid-based drugs market provides a comprehensive perspective on global trends and regional variances. Market trends in the Americas continue to be driven by robust regulatory frameworks and extensive research infrastructure, attracting substantial investments and fostering innovation across both established markets and emerging clusters. Collaborative ecosystems with world-class research institutions and commercial players further strengthen market resilience.

In regions encompassing Europe, the Middle East & Africa, a blend of progressive regulatory reforms and increasing clinical trial activities is contributing to market expansion. This region is characterized by a harmonious blend of advanced research capabilities and strategic governmental incentives, thereby facilitating rapid clinical translations and enabling a smooth integration of breakthrough therapies into therapeutic regimens.

Meanwhile, in the Asia-Pacific region, rapid industrialization, rising healthcare demands, and a surge in technological advancements are collectively igniting market growth. Investments in infrastructure coupled with a rising focus on personalized medicine have catalyzed the development of state-of-the-art genome therapies. Each of these regions plays a significant role in influencing market strategies and expanding the global footprint of nucleic acid-based therapies, reflecting both localized opportunities and broader industry trends.

Based on Region, market is studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The United States is further studied across California, Florida, Illinois, New York, Ohio, Pennsylvania, and Texas. The Asia-Pacific is further studied across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, Thailand, and Vietnam. The Europe, Middle East & Africa is further studied across Denmark, Egypt, Finland, France, Germany, Israel, Italy, Netherlands, Nigeria, Norway, Poland, Qatar, Russia, Saudi Arabia, South Africa, Spain, Sweden, Switzerland, Turkey, United Arab Emirates, and United Kingdom.

Strategic Company Performances and Market Leadership

In a rapidly advancing field marked by innovation and evolving therapeutic approaches, key companies have emerged as market leaders and principal drivers of growth. Prominent organizations such as Alnylam Pharmaceuticals, Inc., Amgen Inc., and Arcturus Therapeutics Holdings Inc. have spearheaded research initiatives that underscore the clinical potential of nucleic acid-based interventions. Moreover, companies like Arrowhead Pharmaceuticals, Inc. and AstraZeneca PLC have positioned themselves at the forefront of strategic collaborations and clinical advancements, further cementing their roles as industry pioneers.

The market is also notably influenced by dynamic contributions from Beam Therapeutics Inc. alongside acclaimed biopharmaceutical enterprises including Biogen, Inc. and BioMarin Pharmaceutical Inc. Furthermore, innovative players such as BioNTech SE and Bluebird Bio, Inc. are continually making strides through novel therapeutic platforms and breakthrough research. The involvement of CRISPR Therapeutics AG, CureVac N.V., and Dynavax Technologies Corporation underscores the commitment to harnessing genetic engineering techniques for therapeutic advancements.

Advancements spearheaded by Editas Medicine, Inc., Eli Lilly and Company, and Evotec SE have been pivotal in transforming market rifts into opportunities, while Generation Bio Co., Gilead Sciences, Inc., and GSK PLC continue to drive clinical research forward. With strategic insights from Intellia Therapeutics, Inc., Ionis Pharmaceuticals, Inc., and Merck & Co., Inc., along with innovative contributions by Moderna, Inc., Novartis AG, Novo Nordisk A/S, Orna Therapeutics, Inc., and Pfizer Inc., the competitive landscape remains both robust and dynamic. The involvement of additional influential organizations such as ProQR Therapeutics N.V., Sangamo Therapeutics, Inc., Sanofi SA, Sarepta Therapeutics, Inc., Silence Therapeutics PLC, Stoke Therapeutics, Inc., Takeda Pharmaceutical Company Limited, Vertex Pharmaceuticals Incorporated, Voyager Therapeutics, Inc., and Wave Life Sciences Ltd. further exemplifies the dynamic nature of this market and its potential for continued growth and innovation.

The report delves into recent significant developments in the Nucleic Acid-Based Drugs Market, highlighting leading vendors and their innovative profiles. These include Alnylam Pharmaceuticals, Inc., Amgen Inc., Arcturus Therapeutics Holdings Inc., Arrowhead Pharmaceuticals, Inc., AstraZeneca PLC, Beam Therapeutics Inc., Biogen, Inc., BioMarin Pharmaceutical Inc., BioNTech SE, Bluebird Bio, Inc., CRISPR Therapeutics AG, CureVac N.V., Dynavax Technologies Corporation, Editas Medicine, Inc., Eli Lilly and Company, Evotec SE, F. Hoffmann-La Roche Ltd., Generation Bio Co., Gilead Sciences, Inc., GSK PLC, Intellia Therapeutics, Inc., Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Moderna, Inc., Novartis AG, Novo Nordisk A/S, Orna Therapeutics, Inc., Pfizer Inc., ProQR Therapeutics N.V., Sangamo Therapeutics, Inc., Sanofi SA, Sarepta Therapeutics, Inc., Silence Therapeutics PLC, Stoke Therapeutics, Inc., Takeda Pharmaceutical Company Limited, Vertex Pharmaceuticals Incorporated, Voyager Therapeutics, Inc., and Wave Life Sciences Ltd.. Actionable Strategies for Market Leadership Advancement

Industry leaders are presented with a range of actionable recommendations to navigate the complexities of the nucleic acid-based drugs market. Foremost, sustaining competitive advantage requires continuous investment in research and development, with a particular emphasis on next-generation sequencing and novel therapeutic platforms. Embracing collaborative research models will enable the pooling of expertise and resources, thereby accelerating the transition from lab-scale studies to clinical applications.

Market leaders should also focus on integrating real-world evidence and data analytics to better understand patient outcomes and refine therapeutic pipelines. Strengthening relationships with regulatory bodies and aligning with evolving global standards can expedite market entry and mitigate compliance risks. Tailored strategies that emphasize precision medicine should aim to capture patient-specific nuances while also addressing broader clinical needs.

Given the dynamic nature of market segmentation, organizations would benefit from a flexible portfolio strategy that is responsive to shifts across drug types, molecule classifications, administration routes, therapeutic areas, and end-user segments. Leveraging digital transformation tools and advanced biomanufacturing capacity will be essential in optimizing supply chains and fostering efficiency. This strategic approach can not only enhance market share but also secure long-term sustainability in the face of evolving global health challenges.

In-depth Conclusion on Market Trends and Strategies

The comprehensive analysis of the nucleic acid-based drugs market reveals a landscape defined by rapid innovation, evolving regulatory practices, and growing clinical potential. Transformations in scientific discovery and technological integration have laid the foundation for novel therapeutic solutions that address previously unmet healthcare needs. The intersection of scientific excellence and strategic market segmentation has provided stakeholders with a nuanced understanding of market dynamics, underscoring the importance of tailored strategies in both clinical and commercial domains.

This executive summary reflects a synthesis of critical insights ranging from transformative market shifts and segmentation insights to regional and corporate strategies that are collectively shaping the future of nucleic acid-based therapeutics. As scientific advancements continue to redefine therapeutic paradigms, industry players are well-advised to pursue collaborative frameworks, invest in groundbreaking research, and adapt to the evolving landscape with agility. The compelling integration of regional insights and strategic corporate insights further signifies the promising trajectory of this vibrant market, positioning it as a key driver of future success in global health innovation.

Table of Contents

1. Preface

• 1.1. Objectives of the Study
• 1.2. Market Segmentation & Coverage
• 1.3. Years Considered for the Study
• 1.4. Currency & Pricing
• 1.5. Language
• 1.6. Stakeholders

2. Research Methodology

• 2.1. Define: Research Objective
• 2.2. Determine: Research Design
• 2.3. Prepare: Research Instrument
• 2.4. Collect: Data Source
• 2.5. Analyze: Data Interpretation
• 2.6. Formulate: Data Verification
• 2.7. Publish: Research Report
• 2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

• 5.1. Market Dynamics
  • 5.1.1. Drivers
    • 5.1.1.1. Rising prevalence of genetic disorders and chronic diseases drives the need for nucleic acid-based drugs
    • 5.1.1.2. Increasing government investments to advance nucleic acid drug manufacturing
  • 5.1.2. Restraints
    • 5.1.2.1. High manufacturing and formulation costs associated with nucleic acid-based drugs
  • 5.1.3. Opportunities
    • 5.1.3.1. Partnership and collaboration among biotech companies to enhance nucleic acid-based drugs
    • 5.1.3.2. Developing next-generation delivery systems to improve the bioavailability of nucleic acid drugs
  • 5.1.4. Challenges
    • 5.1.4.1. Safety and delivery efficacy concerns of nucleic acid-based drugs
• 5.2. Market Segmentation Analysis
  • 5.2.1. Drug Type: Usage of mRNA-based therapeutics due to transformative impact in vaccine development and rapid therapeutic responses during critical health crises
  • 5.2.2. Molecule Type: Widespread adoption of small molecule drugs due to their favorable properties in terms of manufacturing, administration, and cost-effectiveness
  • 5.2.3. Route of Administration: Prevalence of intramuscular injection due to its vital role in vaccine development
  • 5.2.4. Therapeutic Area: Utilization of nucleic acid-based drugs in oncology
  • 5.2.5. End-User: Widespread usage in academic & research institutes driven by need for advanced tools to unravel the intricacies of gene regulation and expression
• 5.3. Porter's Five Forces Analysis
  • 5.3.1. Threat of New Entrants
  • 5.3.2. Threat of Substitutes
  • 5.3.3. Bargaining Power of Customers
  • 5.3.4. Bargaining Power of Suppliers
  • 5.3.5. Industry Rivalry
• 5.4. PESTLE Analysis
  • 5.4.1. Political
  • 5.4.2. Economic
  • 5.4.3. Social
  • 5.4.4. Technological
  • 5.4.5. Legal
  • 5.4.6. Environmental

6. Nucleic Acid-Based Drugs Market, by Drug Type

• 6.1. Introduction
• 6.2. Antisense Oligonucleotides
• 6.3. DNA/RNA Aptamers
• 6.4. mRNA-Based Therapeutics
• 6.5. Nucleoside Analogs
• 6.6. RNA Interference (RNAi) Therapeutics
  • 6.6.1. MicroRNA (MiRNA)
  • 6.6.2. Short Hairpin RNA (ShRNA)
  • 6.6.3. Short Interfering RNA (SiRNA)

7. Nucleic Acid-Based Drugs Market, by Molecule Type

• 7.1. Introduction
• 7.2. Large Molecule
• 7.3. Small Molecule

8. Nucleic Acid-Based Drugs Market, by Route of Administration

• 8.1. Introduction
• 8.2. Inhalation
• 8.3. Intramuscular
• 8.4. Intravenous
• 8.5. Oral
• 8.6. Subcutaneous

9. Nucleic Acid-Based Drugs Market, by Therapeutic Area

• 9.1. Introduction
• 9.2. Cardiovascular Diseases
• 9.3. Infectious Diseases
  • 9.3.1. Bacterial Infections
  • 9.3.2. Fungal Infections
  • 9.3.3. Viral Infections
• 9.4. Metabolic Disorders
• 9.5. Neurological Disorders
• 9.6. Oncology
  • 9.6.1. Hematologic Malignancies
  • 9.6.2. Solid Tumors
• 9.7. Rare Diseases

10. Nucleic Acid-Based Drugs Market, by End-User

• 10.1. Introduction
• 10.2. Academic & Research Institutes
• 10.3. Contract Research Organizations
• 10.4. Hospitals & Clinics
• 10.5. Pharmaceutical & Biotechnology Companies

11. Americas Nucleic Acid-Based Drugs Market

• 11.1. Introduction
• 11.2. Argentina
• 11.3. Brazil
• 11.4. Canada
• 11.5. Mexico
• 11.6. United States

12. Asia-Pacific Nucleic Acid-Based Drugs Market

• 12.1. Introduction
• 12.2. Australia
• 12.3. China
• 12.4. India
• 12.5. Indonesia
• 12.6. Japan
• 12.7. Malaysia
• 12.8. Philippines
• 12.9. Singapore
• 12.10. South Korea
• 12.11. Taiwan
• 12.12. Thailand
• 12.13. Vietnam

13. Europe, Middle East & Africa Nucleic Acid-Based Drugs Market

• 13.1. Introduction
• 13.2. Denmark
• 13.3. Egypt
• 13.4. Finland
• 13.5. France
• 13.6. Germany
• 13.7. Israel
• 13.8. Italy
• 13.9. Netherlands
• 13.10. Nigeria
• 13.11. Norway
• 13.12. Poland
• 13.13. Qatar
• 13.14. Russia
• 13.15. Saudi Arabia
• 13.16. South Africa
• 13.17. Spain
• 13.18. Sweden
• 13.19. Switzerland
• 13.20. Turkey
• 13.21. United Arab Emirates
• 13.22. United Kingdom

14. Competitive Landscape

• 14.1. Market Share Analysis, 2024
• 14.2. FPNV Positioning Matrix, 2024
• 14.3. Competitive Scenario Analysis
  • 14.3.1. SCG Cell Therapy collaborates with A*STAR BTI and NATi to fast-track RNA-based cell and gene therapy in Singapore
  • 14.3.2. FDA approves TRYNGOLZA, fueling a pipeline for nucleic acid therapies
  • 14.3.3. Singapore launches non-GMP NATi mRNA BioFoundry to enhance automated nucleic acid therapeutics research
  • 14.3.4. City Therapeutics secures USD 135 million Series A financing to revolutionize RNA interference therapies and advance next-generation RNAi engineering platform
  • 14.3.5. Evonik partners with KNAUER to expands its portfolio of biosolution
  • 14.3.6. GSK deepens its focus on nucleic acid-based treatments through the acquisition of Elsie Biotechnologies
  • 14.3.7. Aldevron and Acuitas Therapeutics join forces to accelerate next-generation cell and gene therapies
  • 14.3.8. UK invests GBP 4.5 million in advanced nucleic acid drug manufacturing
  • 14.3.9. Asahi Kasei Bioprocess and Axolabs forge a strategic Berlin partnership to build a 59,000 square foot cGMP facility for scalable oligonucleotide therapeutic production
  • 14.3.10. Evonik signs a license with the University of Mainz to commercialize a new class of PEG lipids for nucleic acid delivery
• 14.4. Strategy Analysis & Recommendation
  • 14.4.1. Pfizer Inc.
  • 14.4.2. Novo Nordisk A/S
  • 14.4.3. Moderna, Inc.
  • 14.4.4. Ionis Pharmaceuticals, Inc.

Companies Mentioned

• 1. Alnylam Pharmaceuticals, Inc.
• 2. Amgen Inc.
• 3. Arcturus Therapeutics Holdings Inc.
• 4. Arrowhead Pharmaceuticals, Inc.
• 5. AstraZeneca PLC
• 6. Beam Therapeutics Inc.
• 7. Biogen, Inc.
• 8. BioMarin Pharmaceutical Inc.
• 9. BioNTech SE
• 10. Bluebird Bio, Inc.
• 11. CRISPR Therapeutics AG
• 12. CureVac N.V.
• 13. Dynavax Technologies Corporation
• 14. Editas Medicine, Inc.
• 15. Eli Lilly and Company
• 16. Evotec SE
• 17. F. Hoffmann-La Roche Ltd.
• 18. Generation Bio Co.
• 19. Gilead Sciences, Inc.
• 20. GSK PLC
• 21. Intellia Therapeutics, Inc.
• 22. Ionis Pharmaceuticals, Inc.
• 23. Merck & Co., Inc.
• 24. Moderna, Inc.
• 25. Novartis AG
• 26. Novo Nordisk A/S
• 27. Orna Therapeutics, Inc.
• 28. Pfizer Inc.
• 29. ProQR Therapeutics N.V.
• 30. Sangamo Therapeutics, Inc.
• 31. Sanofi SA
• 32. Sarepta Therapeutics, Inc.
• 33. Silence Therapeutics PLC
• 34. Stoke Therapeutics, Inc.
• 35. Takeda Pharmaceutical Company Limited
• 36. Vertex Pharmaceuticals Incorporated
• 37. Voyager Therapeutics, Inc.
• 38. Wave Life Sciences Ltd.