세계의 CD70 표적 요법 시장 : 임상시험과 시장 기회에 관한 인사이트(2025년)

Global CD70 Targeting Therapies Clinical Trials & Market Opportunity Insight 2025 Report Highlights:

• CD70 Targeting Therapies In Clinical Trials: > 20 Therapies
• CD 70 Targeting Therapies Clinical Trials Insight By Company, Country, Indication and Phase
• Insight On CD70 Targeting Therapy Technology Platforms
• FDA & EMA Designations Insight: Orphan, FTD, RMAT Designation
• Global & Regional Market Development Insight
• Combination Strategies For CD70 Targeting Therapies

CD70 targeting therapies are rapidly gaining recognition as a promising strategy for the treatment of various cancers and immune-related disorders, significantly transforming the therapeutic landscape. CD70, a cell surface protein, is crucial in regulating the immune system, making it an optimal target for therapies designed to selectively attack diseased cells while preserving healthy tissues. This movement towards precision medicine is particularly vital in oncology, where traditional treatments such as chemotherapy and radiation often lead to severe side effects and limited effectiveness.

In clinical practice, CD70 targeting therapies are demonstrating considerable potential in treating hematological malignancies, particularly acute myeloid leukemia (AML), as well as solid tumors like renal cell carcinoma (RCC). AML is particularly challenging to manage with standard therapies, especially in patients who are unsuitable for intensive chemotherapy. Clinical trials focused on CD70 targeted therapies have shown promise in addressing this issue, with monoclonal antibodies and engineered cell therapies offering new hope for patients with few treatment options. The most advanced CD70-targeting therapy currently in clinical development is Cusatuzumab, created by argenx, which is presently undergoing Phase 2 trials in conjunction with chemotherapeutic agents for AML patients. This combination strategy seeks to enhance the effectiveness of Cusatuzumab by tackling resistance mechanisms and improving overall patient outcomes.

The application of CD70 targeting therapies extends beyond cancer treatment. These therapies are also being investigated for autoimmune diseases, viral infections, and graft-versus-host disease (GvHD), although they remain in the early stages of research. In these contexts, where immune responses are dysfunctional, CD70 targeting agents hold the potential to modulate the immune system and restore normal immune function. The expansion of therapeutic applications significantly fuels interest in this sector, as it broadens the potential market for these treatments.

In commercial terms, the US stands as hub for CD70 targeting therapy research and development. A robust ecosystem comprising biotechnology companies, pharmaceutical enterprises, and research institutions has driven the advancement of these therapies. Notable institutions such as Baylor College of Medicine, the National Institutes of Health, and cancer centers like City of Hope are conducting crucial clinical trials. Furthermore, regulatory support from the US FDA, including the Fast Track Designation for Adicet Bio's ADI-270 and the Regenerative Medicine Advanced Therapy designation for Allogene Therapeutics' ALLO-316, has expedited the development and commercialization processes. This regulatory endorsement is vital in facilitating access to new treatments, positioning the US as the heart for both clinical development and market introduction.

China is emerging as a significant contender in the global CD70 targeting therapy landscape. The country's rapidly growing biotechnology sector, bolstered by increased investments and partnerships with international companies, has enabled swift advancements in innovative therapies. Chinese research institutions are increasingly involved in clinical trials, while local biotech firms are progressing towards the commercialization of CD70 targeting therapies.

The intensifying competition within the CD70 targeting therapy market is fostering innovation, with several companies, including Allogene Therapeutics, Seagen (Pfizer), and CRISPR Therapeutics, developing novel treatments. These organizations are engaged in comprehensive preclinical and clinical research to assess the safety and efficacy of their therapies, thereby enhancing the therapeutic potential of CD70 targeted interventions. As more therapies enter clinical trials and yield favorable outcomes, the commercial opportunities for CD70 targeting therapies are expanding.

In conclusion, the integration of favorable clinical results and a dynamic commercial landscape establishes CD70 targeting therapies as a crucial component of the future of precision medicine. As an increasing number of companies and research organizations dedicate resources to these therapies, their capacity to tackle a diverse array of diseases expands, indicating the prospect of both clinical and commercial achievements ahead.

Table of Contents

1. Introduction To CD70 Targeting Therapy

• 1.1 CD70 Targeting Therapy Overview
• 1.2 The Prerequisite For CD70 Targeting Therapy
• 1.3 Dual Role of CD70 As Diagnostic & Prognostic Biomarker

2. CD70 Targeting Therapeutic Approaches

• 2.1 Monoclonal Antibody
• 2.2 Bispecific Antibody
• 2.3 Tetraspecific Antibody
• 2.4 CAR T Cell Therapy
• 2.5 Antibody Drug Conjugate
• 2.6 CAR-NK Therapy

3. CD70 Targeting Therapies Clinical Research & Development By Indications

• 3.1 Leukemia
• 3.2 Lymphoma
• 3.3 Gynecologic Cancer
• 3.4 Renal Cell Carcinoma
• 3.5 Lung Cancer
• 3.6 Autoimmune & Inflammatory Disease
• 3.7 Viral Infections

4. Global CD70 Targeting Therapies Clinical Trials Overview

• 4.1 By Phase
• 4.2 By Country
• 4.3 By Company
• 4.4 By Indication
• 4.5 By Priority Status
• 4.6 Patient Segment

5. CD70 Targeting Therapies Regulatory Designations: Fast Track & Orphan Designation

6. Global CD70 Targeting Therapies Clinical Trials Insight

• 6.1 Preclinical
• 6.2 Phase I
• 6.3 Phase I/II
• 6.4 Phase II

7. CD70 Targeting Therapies Development Platforms By Company & Technology

• 7.1 AlloCAR T Platform
• 7.2 Gamma Delta Cell Platform
• 7.3 Tailwind Platform
• 7.4 DARPin Platform
• 7.5 SIMPLE Antibody Platform
• 7.6 Potelligent Technology
• 7.7 Off The Shelf Allogeneic Manufacturing

8. Global CD70 Targeting Therapies Current Market Trend & Developments

• 8.1 Current Market Outline
• 8.2 Future Market Forecast

9. CD70 Targeting Therapies Market Opportunity & Clinical Trends By Region

• 9.1 US
• 9.2 China
• 9.3 Europe

10. Combination Strategies For CD70 Targeting Therapies

• 10.1 In Combination With Immunotherapy
• 10.2 In Combination With Epigenetic Modulators
• 10.3 In Combination With Targeted Therapy
• 10.4 In Combination With Oncolytic Virus Therapy
• 10.5 In Combination With Chemotherapy

11. Global CD70 Targeting Therapies Market Dynamics

• 11.1 Market Drivers
• 11.2 Market Challenges

12. Competitive Landscape

• 12.1 Adaptimmune
• 12.2 Adicet Bio
• 12.3 Allogene Therapeutics
• 12.4 Ambrx (Johnson & Johnson)
• 12.5 Chongqing Precision Biotech
• 12.6 Chinook Therapeutics (Novartis)
• 12.7 CRISPR Therapeutics
• 12.8 ImmuneOnco Biopharma
• 12.9 Pfizer
• 12.10 Poseida Therapeutics