녹아웃 마우스 모델 시장 보고서 : 동향, 예측 및 경쟁 분석(-2031년)

The future of the global knock out mouse model market looks promising with opportunities in the hospital and laboratory markets. The global knock out mouse model market is expected to grow with a CAGR of 4.1% from 2025 to 2031. The major drivers for this market are the increasing demand for personalized medicine, the rising prevalence of genetic disorders, and the growing adoption of precision research.

• Lucintel forecasts that, within the type category, conditional knockout mouse is expected to witness the highest growth over the forecast period.
• Within the application category, laboratory is expected to witness higher growth.
• In terms of region, APAC is expected to witness the highest growth over the forecast period.

Emerging Trends in the Knock Out Mouse Model Market

The knock out mouse model market is being transformed by some major emerging trends that are radically altering the nature of genetic research and drug discovery. These trends are responding to the imperative for increased precision, productivity, and biological relevance in preclinical studies. The trend is toward more advanced models and integrated workflows that yield richer insights into disease mechanisms. These new trends are not just advancing the functional capability of knock out mice but also broadening their applications across more scientific fields.

• CRISPR-Cas9 Gene Editing Application: One of the key trends is the use of CRISPR-Cas9 technology for creating knock out mouse models on a widespread scale. This powerful gene editing method is quicker, faster, and more efficient and cost-effective than conventional techniques. The effect is a substantial decrease in the time and cost involved to develop new models, which is more within the reach of a broad array of researchers. This technology is speeding up the pace of genetic studies and allowing the development of more complex and accurate models.
• Conditional and Humanized Model Development: The industry is witnessing an increasing trend towards the construction of conditional and humanized knock out mouse models. Conditional knock out mice enable gene deletion at a particular time or tissue, and this offers a closer study of gene function. Humanized models with human genes or tissues provide a more physiologically relevant system for drug testing. The outcome is a more reliable prediction of drug efficacy and safety in humans, which can really lower drug failure in clinical trials.
• Computational Biology-AI Integration: One of the major trends is the combination of computational biology and artificial intelligence (AI) with knock out mouse model studies. AI is utilized to interpret the huge amount of phenotypic data produced from these models and to determine the function of unidentified genes. The result is a more effective and data-oriented approach to research. This convergence assists scientists to discover new drug targets and decipher intricate genotype-phenotype associations more efficiently, speeding the whole discovery process.
• Movement towards Outsourcing and CRO Services: The market is observing a movement towards outsourcing the production and development of knock out mouse models to expert contract research organizations (CROs). This enables biotech and pharmaceutical firms to concentrate on their primary research functions without the exorbitant expense of a separate vivarium and personnel. The effect is improved efficiency, cost reduction, and access to more diversity of expertise and specialized models. This trend is democratizing access to knock out mice and facilitating growth in the CRO industry.
• Expansion into Personalized Medicine: There has been increased utilization of the knock out mouse model in personalized medicine. Scientists are developing patient-derived xenograft (PDX) and other patient-specific models on which they check the efficacy of various treatments on an individual's tumor or disease. The contribution is the creation of a very valuable tool for precision medicine, where therapies are customized based on a patient's unique genomic makeup. This method has the ability to transform cancer therapy and other therapies of a tailored nature.

Overall, these new developments are essentially transforming the knock out mouse model industry. Adoption of CRISPR-Cas9 and advanced model development are refining precision and biological validity of research. Integration of AI and outsourcing are enhancing efficiency and accessibility. The move into personalized medicine is establishing new, high-value applications for these models. These shifts are together contributing to a more innovative, cost-effective, and variable market that is cutting-edge for contemporary biomedical investigation.

Recent Developments in the Knock Out Mouse Model Market

Current advances in the knock out mouse model market are centered on enhancing the speed, accuracy, and complexity of model creation and use. The advances are necessitated by the need to keep up with the exponentially increasing requirements of contemporary drug discovery as well as explore more intricate biological questions. The field is shifting away from a dependence on basic, constitutive knock outs toward a more sophisticated approach that utilizes state-of-the-art technology to develop models that better simulate human disease, ultimately yielding more consistent preclinical information.

• Cross-Disciplinary Adoption of CRISPR-Cas9 Technology: One of the most important developments is the cross-disciplinary adoption of CRISPR-Cas9 technology for creating knock out mouse models. This gene editing technology makes it possible to produce knock outs with unrivaled speed and accuracy, frequently in a few months instead of years. The effect is a profound acceleration of the research pipeline, as it cuts dramatically the time to produce a new model. This innovation has made custom mouse models accessible to anyone and stimulated innovation across the industry.
• Humanization Commercialization of Mouse Models: Commercialization and standardization of mouse models with humanization have proceeded enormously. Such models are developed to contain human genes, cells, or tissues, and are now a better representative and predictive model for the study of human disease, notably in immunology and cancer. The benefit is the potential to have researchers test human-specific drugs and treatments in a preclinical environment with increased assurance, minimizing the risk of failure in follow-on clinical trials.
• Development of Large-Scale Mouse Model Repositories: One of the important developments is the creation of large-scale mouse model repositories, as preserved by the International Mouse Phenotyping Consortium. These repositories contain enormous collections of knock out mice, offering easy access to thousands of various models. The effect is a worldwide collaborative effort minimizing redundancy in research and offering a standardized resource for large-scale gene function study, hence speeding up the identification of gene-disease associations.
• Progress in Conditional Knock out Systems: Recent research has seen a major leap forward in conditional knock out systems that permit the spatiotemporal control of gene ablation. These systems, for example, Cre-Lox, make it possible for scientists to switch a gene on or off in a given time and tissue. The consequence is a more sensitive and specific investigation of gene function free from the confounding influences of embryonic lethality or ubiquitous gene deletion, resulting in more directed and consistent research findings.
• Enhanced Utilization of Mouse Models in COVID-19 Research: One such new trend has been the heightened utilization of mouse models in COVID-19 research. Researchers developed knock out mice that have the human ACE2 receptor to research the pathogenesis of the virus and test treatments and vaccines. The effect is a fast and efficient preclinical model for researching an emerging pathogen. It has shown the important function that knock out mouse models have in responding to public health crises and their versatility in modeling disease.

In summary, all these advances are collectively transforming the knock out mouse model market such that it is becoming more efficient, accurate, and advanced. The large-scale adoption of CRISPR-Cas9 and commercial availability of humanized models are improving the quality and applicability of preclinical studies. The organization of large repositories and development of conditional knock out systems are enhancing accessibility and accuracy. These developments are making the market a critical and active force for biomedical breakthrough, pushing innovation and new therapy development.

Strategic Growth Opportunities in the Knock Out Mouse Model Market

The knock out mouse model market has a number of strategic opportunities for growth across primary applications, fueled by its inevitability as a tool for deciphering gene function and disease. Through targeting such application-specific segments, firms can use their genetic engineering expertise to help meet some of the most critical needs in life sciences and achieve a competitive edge. The market is shifting toward increasing specialization and focus, generating new value propositions and new top-line streams beyond mere basic research into high-impact areas such as personalized medicine and therapeutic development.

• Business in Oncology and Cancer Research: A key strategic growth business opportunity exists in the use of knock out mouse models for cancer research and oncology. These models are critical to investigate tumor biology, discover novel drug targets, and to assay the effectiveness of new cancer drugs. The opportunity is to offer a broad spectrum of cancer-specific models, such as patient-derived xenografts (PDX), and to provide comprehensive preclinical services. The benefit is the potential to collaborate with biotechnology and pharmaceutical firms to speed up the development of life-saving cancer therapies.
• Expansion into Personalized Medicine: The market offers a tremendous growth potential in the use of knock out mouse models for personalized medicine. By developing patient-specific models with specific genetic mutations, scientists can try out the efficacy of various drugs and treatments prior to giving them to the patient. The market opportunity is to create and sell platforms to produce such highly customized models. The value is in having the ability to offer an enabling tool for precision medicine, resulting in improved and targeted therapies for individuals and a high-value application.
• Use in Neurodegenerative Disease Research: There is another tremendous growth opportunity in the use of knock out mouse models in research on neurodegenerative diseases like Alzheimer's and Parkinson's disease. These models are essential for examining the intricate genetic and molecular pathways of these diseases, for which there are at present few useful treatments. The potential is to supply specialized models accurately representing the human disease. The benefit is the potential to advance a field with huge unmet medical need, spurring innovation and potential breakthroughs in therapy.
• Immunology and Infectious Disease Research Growth: A strategic opportunity for growth exists in the use of knock out mouse models for infectious disease and immunology research. Humanized mouse models are especially useful here for research on the human immune response to pathogens as well as for the testing of vaccines and immunotherapies. The opportunity exists to develop and market a portfolio of humanized models. The effect is the potential to be a central contribution to global health initiatives, including the creation of vaccines for pandemics, and to enable the emerging industry of immunotherapy.
• Focusing on Academic and Government Research Institutions: One of the major growth possibilities is to focus on academic and government research institutions. Pharmaceutical corporations are large customers, but these institutions are a huge and steady market for knock out mouse models for basic research. The potential is to offer a broad variety of standardized, low-cost models and support services. The effect is extended market reach and the capability to establish long-term relationships with a wide variety of research teams, thus having an impact on future scientific breakthroughs.

Overall, these strategic opportunity growths are redefining the knock out mouse model market by emphasizing application-based requirements. By focusing on oncology, personalized medicine, neurodegenerative disorders, immunology, and the academic market, businesses are shifting towards a high-value and specialized model. This is promoting a market wherein an understanding of application needs and the provision of customized solutions are driving success, which places knock out mice as a core technology for a broad spectrum of life sciences applications.

Knock Out Mouse Model Market Driver and Challenges

The knock out mouse model market is dictated by a multifaceted interplay of key drivers propelling its growth and major pitfalls tempering its expansion. The growth of the markets is inherently driven by the escalating demand for cutting-edge tools for drug discovery and the worldwide bid to hasten biomedical research. Yet, such advancement is hampered by serious obstacles, such as ethical issues, the exorbitant cost of models, and the complexity of producing and characterizing them. The interplay between these drivers determines the direction and speed of market development.

The factors responsible for driving the knock out mouse model market include:

1. Growing Research and Development Expenditures: One major impetus is growing R&D expenditures in the biotechnology and pharmaceutical industries. Businesses feel compelled to bring new and better drugs to market for various conditions. Knock out mouse models are a must-have for preclinical evaluation and disease mechanism studies. This ongoing investment in drug development and discovery makes for a robust and consistent demand for these models, fueling growth and advancement in the market.

2. Gene Editing Technologies Advancements: The main driver is the ongoing development of gene editing technologies, especially CRISPR-Cas9. This has opened up a whole new way of producing knock out models, and the process now is quicker, more accurate, and cheaper. The technological advancements have alleviated a major bottleneck in research and enabled researchers to produce more intricate models, which in turn drives the market by increasing the capabilities and uses of knock out mice.

3. Increasing Demand for Personalized Medicine: Increasing demand for personalized and precision medicine is one of the key drivers. Personalized medicine depends on a comprehensive understanding of the genetic makeup of an individual and how it affects disease and treatment response. Patient-derived knock out mouse models are critical for testing and validating these personalized strategies. This trend is establishing a new, high-value use of knock out mice and is propelling their use in clinical research.

4. Increasing Chronic Diseases: The rising global incidence of chronic diseases like cancer, diabetes, and cardiovascular diseases is the key driver. All these diseases necessitate a large amount of research to find their underlying causes and new treatments. Knock out mice are employed to investigate the genetic origin of such conditions and to test for possible therapeutics. Increasing incidence of such diseases generates an ongoing demand for new research reagents, and hence for knock out mice.

5. Growth of Contract Research Organizations: The growth of the contract research organization sector is a major driver. Numerous pharmaceutical and biotechnology organizations are subcontracting their preclinical research to CROs to minimize costs as well as tap into specialized expertise. These CROs are heavy customers for knock out mouse models. This trend is compelling demand for both the models themselves and accompanying services, including breeding, phenotyping, and bespoke model creation, thus propelling market development.

Challenges in the knock out mouse model market are:

1. Ethical Issues and Regulatory Barriers: A major challenge is the ethical issues and strict regulatory guidelines around the use of animals in research. Public perception and animal welfare organizations may generate pressure to limit or eliminate animal testing. This necessitates a lengthy and complicated regulatory approval process for studies involving animals, which tends to delay the research and increase the expense. This ethical controversy and regulation serve as a significant restraint on the market.

2. High Model Generation and Maintenance Cost: The market is confronted with difficulty because of the high cost involved in the generation and maintenance of knock out mouse models. Establishing a new custom model is quite costly, and the constant expenses of sheltering, nourishing, and breeding a large mouse colony are out of reach for many research facilities. Such a high expenditure can be a threshold to entry for smaller laboratories and can restrict the scope of larger studies.

3. Lack of Predictive Accuracy and Complexity: The other major challenge is the complexity of disease modeling and the limitations of extrapolating predictions from mice to man. Although knock out mice are a valuable tool, they are not ideal models of human disease. The physiological differences between man and mouse can result in a lack of predictive accuracy, which is a cause of concern for drug developers. This complexity and potential for error pose a major challenge for the market.

The knock out mouse model market is witnessing dynamic growth, stimulated by the synergy of increased R&D expenditure and impressive technology developments. The trend in markets is favorably aided by increasing demand for personalized medicine and a shift in attention towards chronic disease studies. Yet, its full potential is threatened by the multifaceted challenges of ethical issues, high model costs, and the limitations inherent in animal models' ability to predict human outcomes.

List of Knock Out Mouse Model Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. With these strategies knock out mouse model companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the knock out mouse model companies profiled in this report include-

• Envigo
• GenOway
• Cyagen Biosciences
• Charles River Laboratories International
• TransGenic

Knock Out Mouse Model Market by Segment

The study includes a forecast for the global knock out mouse model market by type, application, and region.

Knock Out Mouse Model Market by Type [Value from 2019 to 2031]:

• Constitutive Knockout Mouse
• Conditional Knockout Mouse
• Protein Function Knockout Mouse

Knock Out Mouse Model Market by Application [Value from 2019 to 2031]:

• Hospital
• Laboratory
• Others

Country Wise Outlook for the Knock Out Mouse Model Market

The knock out mouse model market is a vital part of contemporary biomedical research, being an invaluable instrument for uncovering the function of genes and mechanisms of disease. Developments have been pushed forward in recent times by a convergence of sophisticated genetic engineering strategies, an expanding emphasis on personalized medicine, and the rising sophistication of therapeutic research. The market is evolving with a shift toward more sophisticated models, such as conditional and humanized mice, which provide a more accurate representation of human disease. This evolution is enabling researchers to accelerate drug discovery and develop more targeted and effective treatments for a wide range of diseases.

• United States: United States market for knock out mouse models is a world leader, backed by huge government and private investments in biomedical research. Current trends revolve around the universal adoption of CRISPR-Cas9 technology, which has optimized gene editing to be quicker, more accurate, and less expensive. There is also a strong shift towards outsourcing the generation and breeding of models to specialist contract research organizations. This market is underpinned by a robust pharmaceutical and biotechnology sector, with a special emphasis on oncology and rare disease research.
• China: China's knock out mouse model market is growing strongly, driven by high government investment in life sciences and a growing domestic biotechnology industry. Recent advances have included an emphasis on establishing large-scale mouse model repositories and an emphasis on innovative gene editing technologies. Chinese firms are providing a vast variety of custom mouse models at affordable prices, increasing accessibility to the technology. The industry also witnesses growth in partnerships between universities and private companies aimed at advancing research and development.
• Germany: The German knock out mouse model market is distinguished by a robust academic research base and a stringent quality and ethical animal care standard. Recent advances are towards the generation of highly specific and physiologically relevant conditional knock out models to evaluate gene function in a spatiotemporal fashion. German scientists also lead the way in applying these models to advanced disease fields such as neurodegeneration and immunology. The industry enjoys a mature network of research establishments and robust regulatory system to guarantee high-standard research.
• India: The Indian knock out mouse model industry is a growth-emerging market, fostered by expanding investment in life sciences R&D and a developing contract research sector. Recent trends are aiming for enhanced access to superior quality mouse models and local expertise in genetic engineering. The market is experiencing increased collaboration between Indian and overseas companies to tap expertise and technology. This expansion is further assisted by a huge reservoir of experienced scientific experts and an increasing emphasis on drug development and discovery.
• Japan: Japan's knock out mouse model market is highly advanced in terms of technology and is extremely innovative in nature, with a special emphasis on accuracy and high-level model usage. Recent advancements have seen a tendency towards the utilization of humanized mouse models for the study of immunology and infectious diseases. Japanese scientists also dominate the use of knock out mice in stem cell and regenerative medicine research. The industry is backed by a solid platform of industrial and academic research, with industry leaders heavily investing in R&D to create new-generation animal models and associated services.

Features of the Global Knock Out Mouse Model Market

• Market Size Estimates: Knock out mouse model market size estimation in terms of value ($B).
• Trend and Forecast Analysis: Market trends (2019 to 2024) and forecast (2025 to 2031) by various segments and regions.
• Segmentation Analysis: Knock out mouse model market size by type, application, and region in terms of value ($B).
• Regional Analysis: Knock out mouse model market breakdown by North America, Europe, Asia Pacific, and Rest of the World.
• Growth Opportunities: Analysis of growth opportunities in different type, application, and regions for the knock out mouse model market.
• Strategic Analysis: This includes M&A, new product development, and competitive landscape of the knock out mouse model market.

Analysis of competitive intensity of the industry based on Porter's Five Forces model.

This report answers following 11 key questions:

• Q.1. What are some of the most promising, high-growth opportunities for the knock out mouse model market by type (constitutive knockout mouse, conditional knockout mouse, and protein function knockout mouse), application (hospital, laboratory, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?
• Q.2. Which segments will grow at a faster pace and why?
• Q.3. Which region will grow at a faster pace and why?
• Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?
• Q.5. What are the business risks and competitive threats in this market?
• Q.6. What are the emerging trends in this market and the reasons behind them?
• Q.7. What are some of the changing demands of customers in the market?
• Q.8. What are the new developments in the market? Which companies are leading these developments?
• Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?
• Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?
• Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

Table of Contents

1. Executive Summary

2. Market Overview

• 2.1 Background and Classifications
• 2.2 Supply Chain

3. Market Trends & Forecast Analysis

• 3.2 Industry Drivers and Challenges
• 3.3 PESTLE Analysis
• 3.4 Patent Analysis
• 3.5 Regulatory Environment

4. Global Knock Out Mouse Model Market by Type

• 4.1 Overview
• 4.2 Attractiveness Analysis by Type
• 4.3 Constitutive Knockout Mouse: Trends and Forecast (2019-2031)
• 4.4 Conditional Knockout Mouse: Trends and Forecast (2019-2031)
• 4.5 Protein Function Knockout Mouse: Trends and Forecast (2019-2031)

5. Global Knock Out Mouse Model Market by Application

• 5.1 Overview
• 5.2 Attractiveness Analysis by Application
• 5.3 Hospital: Trends and Forecast (2019-2031)
• 5.4 Laboratory: Trends and Forecast (2019-2031)
• 5.5 Others: Trends and Forecast (2019-2031)

6. Regional Analysis

• 6.1 Overview
• 6.2 Global Knock Out Mouse Model Market by Region

7. North American Knock Out Mouse Model Market

• 7.1 Overview
• 7.2 North American Knock Out Mouse Model Market by Type
• 7.3 North American Knock Out Mouse Model Market by Application
• 7.4 United States Knock Out Mouse Model Market
• 7.5 Mexican Knock Out Mouse Model Market
• 7.6 Canadian Knock Out Mouse Model Market

8. European Knock Out Mouse Model Market

• 8.1 Overview
• 8.2 European Knock Out Mouse Model Market by Type
• 8.3 European Knock Out Mouse Model Market by Application
• 8.4 German Knock Out Mouse Model Market
• 8.5 French Knock Out Mouse Model Market
• 8.6 Spanish Knock Out Mouse Model Market
• 8.7 Italian Knock Out Mouse Model Market
• 8.8 United Kingdom Knock Out Mouse Model Market

9. APAC Knock Out Mouse Model Market

• 9.1 Overview
• 9.2 APAC Knock Out Mouse Model Market by Type
• 9.3 APAC Knock Out Mouse Model Market by Application
• 9.4 Japanese Knock Out Mouse Model Market
• 9.5 Indian Knock Out Mouse Model Market
• 9.6 Chinese Knock Out Mouse Model Market
• 9.7 South Korean Knock Out Mouse Model Market
• 9.8 Indonesian Knock Out Mouse Model Market

10. ROW Knock Out Mouse Model Market

• 10.1 Overview
• 10.2 ROW Knock Out Mouse Model Market by Type
• 10.3 ROW Knock Out Mouse Model Market by Application
• 10.4 Middle Eastern Knock Out Mouse Model Market
• 10.5 South American Knock Out Mouse Model Market
• 10.6 African Knock Out Mouse Model Market

11. Competitor Analysis

• 11.1 Product Portfolio Analysis
• 11.2 Operational Integration
• 11.3 Porter's Five Forces Analysis
  • Competitive Rivalry
  • Bargaining Power of Buyers
  • Bargaining Power of Suppliers
  • Threat of Substitutes
  • Threat of New Entrants
• 11.4 Market Share Analysis

12. Opportunities & Strategic Analysis

• 12.1 Value Chain Analysis
• 12.2 Growth Opportunity Analysis
  • 12.2.1 Growth Opportunities by Type
  • 12.2.2 Growth Opportunities by Application
• 12.3 Emerging Trends in the Global Knock Out Mouse Model Market
• 12.4 Strategic Analysis
  • 12.4.1 New Product Development
  • 12.4.2 Certification and Licensing
  • 12.4.3 Mergers, Acquisitions, Agreements, Collaborations, and Joint Ventures

13. Company Profiles of the Leading Players Across the Value Chain

• 13.1 Competitive Analysis
• 13.2 Envigo
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.3 GenOway
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.4 Cyagen Biosciences
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.5 Charles River Laboratories International
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing
• 13.6 TransGenic
  • Company Overview
  • Knock Out Mouse Model Business Overview
  • New Product Development
  • Merger, Acquisition, and Collaboration
  • Certification and Licensing

14. Appendix

• 14.1 List of Figures
• 14.2 List of Tables
• 14.3 Research Methodology
• 14.4 Disclaimer
• 14.5 Copyright
• 14.6 Abbreviations and Technical Units
• 14.7 About Us
• 14.8 Contact Us