세계의 세팔로스포린 의약품 시장 : 점유율 분석, 산업 동향, 통계, 성장 예측(2025-2030년)

The cephalosporin drugs market is valued at USD 20.63 million in 2025 and is forecast to climb to USD 21.25 million by 2030, reflecting a 3.02% CAGR.

Steady demand endures because cephalosporins remain first-line therapies for severe hospital infections, even as competitive generics and stewardship rules limit rapid expansion. Uptake of newer generations designed for multidrug-resistant pathogens, broader surgical volumes requiring prophylaxis, and the World Health Organization's AWaRe framework, which encourages cephalosporin access in low- and middle-income countries, underpin growth. On the other hand, tender-based procurement depresses prices, and the rise of non-antibiotic modalities such as phage therapy threatens long-term volumes. Competitive differentiation now hinges on beta-lactamase-inhibitor combinations, long-acting depot injections for outpatient therapy, and expedited regulatory pathways that add exclusivity for qualified infectious disease products.

Global Cephalosporin Drugs Market Trends and Insights

Escalating Prevalence of MDR Gram-Negative Infections

Multidrug-resistant gram-negative pathogens now dominate hospital infection profiles, pushing clinicians toward fifth-generation cephalosporins that retain activity against ESBL-producing Enterobacterales. Klebsiella pneumoniae ST307 isolates show 85% resistance to third-generation agents, accelerating the adoption of ceftobiprole and cefepime-enmetazobactam combinations that remain effective. The Infectious Diseases Society of America's 2024 guidance positions these advanced drugs as recommended therapy, enabling premium pricing despite generic competition. Hospitals also deploy combination regimens with beta-lactamase inhibitors, especially in intensive care units, creating long-run volume support for high-potency cephalosporin variants.

Growth in Surgical Procedures & Hospital-Acquired Infections

Increasing global surgical volumes correlate directly with cephalosporin prophylaxis demand. Guidelines endorse first- and second-generation agents for most interventions, achieving 3% infection rates when dozed within one hour before incision. Hospital-acquired pneumonia and sepsis protocols rely on early broad-spectrum coverage; studies demonstrate notable mortality reductions when cephalosporins are administered promptly. Outpatient surgery growth further expands need for short-acting formulations, while emerging economies add substantial new surgical capacity, sustaining the cephalosporin drugs market.

Generic Price Erosion from Tender-Based Procurement

Patent expirations invite numerous generic entrants, and centralized tenders drive prices down swiftly, particularly for third-generation drugs. Hospitals that implemented strict restriction policies documented 46.2% spending drops after switching to the lowest-priced generics. Manufacturers must now lean on manufacturing scale or exit low-margin segments, intensifying consolidation within the cephalosporin drugs market.

Other drivers and restraints analyzed in the detailed report include:

1. Expedited QIDP & Antimicrobial Pull-Incentive Programs
2. WHO AWaRe Re-Classification Boosting LMIC Usage
3. Global Antibiotic Stewardship Restrictions on Broad Use

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Third-generation molecules held 44.6% of the cephalosporin drugs market share in 2024, owing to dependable coverage across respiratory, urinary, and intra-abdominal infections. However, continuous resistance pressure propels fifth-generation agents, which are forecast to clock a 9.1% CAGR through 2030. Ceftobiprole's 2024 approval illustrates how expanded gram-positive and gram-negative spectra elevate therapeutic value and sustain premium pricing. Fourth-generation cefepime, paired with modern beta-lactamase inhibitors, also gains traction because composite response rates top 79.1% in difficult urinary tract infections. The cephalosporin drugs market size for advanced generations is therefore widening faster than volumes indicate, as hospitals pay a premium for resistance-breaking efficacy.

Fiscal incentives embedded in QIDP statutes prolong exclusivity for novel combinations, encouraging firms to position fifth-generation drugs at the apex of formulary hierarchies. Nonetheless, cost-focused payers favor third-generation generics for routine cases, forcing manufacturers to balance high-margin innovation with high-volume legacy franchises. This dynamic generates a bifurcated competitive field where pricing strategy and antimicrobial performance co-determine adoption.

Prescription medicines commanded 80.3% of 2024 revenue because complex dosing regimens and resistance concerns require medical oversight. Yet the OTC sub-segment advances at a 6.36% CAGR as regulators in select Asia-Pacific markets permit pharmacist-guided supply for mild infections. This controlled liberalization lowers patient wait times and streamlines primary care burdens, broadening participation in the cephalosporin drugs market.

Growing digital pharmacies further bolsters OTC uptake by integrating virtual consultation modules that satisfy legal requisites for antibiotic sales. In contrast, high-income markets persist with prescription status, citing stewardship priorities. The resulting patchwork regulatory canvas leaves multinational firms tailoring SKU portfolios to disparate access models while maintaining vigilance on safety and resistance monitoring.

The Cephalosporins Market is Segmented by Generation (First, Second-Generation, and More), Prescription Type (Prescription and OTC), Route of Administration (Oral and Parenteral), Indication (Respiratory Tract, Urinary Tract Infections, and More), Indication (Hospital Pharmacies, and More), and by Geography (North America, Europe, Asia-Pacific, and More). The Market Sizes and Forecasts are Provided in Terms of Value (USD).

Geography Analysis

North America led with 31.6% revenue in 2024, due to advanced hospitals, high surgical throughput, and QIDP-driven innovation pipelines. U.S. antimicrobial stewardship rules ensure rational use without compromising timely access, and Canada's provincial formularies prioritize cost-effectiveness while retaining broader-spectrum options for critical care. Large payer systems negotiate steep volume discounts, restraining headline growth but cementing baseline demand for both generic and premium cephalosporins across the cephalosporin drugs market.

Asia-Pacific registers the fastest 7.9% CAGR through 2030, underpinned by capacity expansions in China and India, rising health expenditures, and alarming resistance rates that necessitate advanced formulations. Partnerships such as Orchid Pharma-Cipla's launch of cefepime-enmetazobactam underscore local manufacturing's role in broadening access. Government tenders linked to universal health schemes stimulate large-volume purchases, although intense price competition requires firms to balance profitability with scale.

Europe maintains steady mid-single-digit growth as evidence-based prescribing and rapid diagnostics temper unnecessary usage. Harmonized EMA approvals allow simultaneous launches with the U.S., enabling companies to leverage unified marketing campaigns across major markets. The United Kingdom's post-Brexit regulatory adjustments introduce moderate uncertainty, but overall adherence to WHO stewardship guidance creates predictable demand patterns that privilege newer combinations able to overcome endemic ESBL prevalence.

1. Pfizer
2. Roche
3. Merck
4. GlaxoSmithKline
5. Teva Pharmaceutical Industries
6. Baxter
7. Lupin
8. Macleods Pharmaceuticals
9. Mankind Pharma
10. Sun Pharmaceuticals Industries
11. Abbvie
12. Bristol-Myers Squibb
13. Eli Lilly and Company
14. Sandoz (Novartis generics)
15. Aurobindo Pharma
16. Hikma Pharmaceuticals
17. Fresenius
18. Cipla
19. Shionogi
20. Zydus Lifesciences Ltd

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

• 1.1 Study Assumptions & Market Definition
• 1.2 Scope of the Study

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Escalating Prevalence of MDR Gram-Negative Infections
  • 4.2.2 Growth In Surgical Procedures & Hospital-Acquired Infections
  • 4.2.3 Expedited QIDP & Antimicrobial Pull-Incentive Programs
  • 4.2.4 Who Aware Re-Classification Boosting LMIC Usage
  • 4.2.5 Long-Acting Parenteral Depot Formulations for OPAT
  • 4.2.6 Increasing Veterinary Approvals & Agri-Antibiotic Use
• 4.3 Market Restraints
  • 4.3.1 Generic Price Erosion from Tender-Based Procurement
  • 4.3.2 Global Antibiotic Stewardship Restrictions on Broad Use
  • 4.3.3 Poor Roi Despite Pull Incentives Deterring R&D
  • 4.3.4 Emerging Non-Antibiotic Modalities (Phage, Crispr)
• 4.4 Supply Chain Analysis
• 4.5 Regulatory Landscape
• 4.6 Porter's Five Forces
  • 4.6.1 Threat of New Entrants
  • 4.6.2 Bargaining Power of Buyers
  • 4.6.3 Bargaining Power of Suppliers
  • 4.6.4 Threat of Substitute Products
  • 4.6.5 Intensity of Competitive Rivalry

5 Market Size & Growth Forecasts (Value)

• 5.1 By Generation
  • 5.1.1 First-generation
  • 5.1.2 Second-generation
  • 5.1.3 Third-generation
  • 5.1.4 Fourth-generation
  • 5.1.5 Fifth-generation
• 5.2 By Prescription Type
  • 5.2.1 Prescription Drugs
  • 5.2.2 OTC Drugs
• 5.3 By Route of Administration
  • 5.3.1 Oral
  • 5.3.2 Parenteral
• 5.4 By Indication
  • 5.4.1 Respiratory Tract Infections
  • 5.4.2 Urinary Tract Infections
  • 5.4.3 Skin & Soft-Tissue Infections
  • 5.4.4 Sepsis & Meningitis
• 5.5 By Distribution Channel
  • 5.5.1 Hospital Pharmacies
  • 5.5.2 Retail Pharmacies
  • 5.5.3 Online Pharmacies
• 5.6 By Geography
  • 5.6.1 North America
    • 5.6.1.1 United States
    • 5.6.1.2 Canada
    • 5.6.1.3 Mexico
  • 5.6.2 Europe
    • 5.6.2.1 Germany
    • 5.6.2.2 United Kingdom
    • 5.6.2.3 France
    • 5.6.2.4 Italy
    • 5.6.2.5 Spain
    • 5.6.2.6 Rest of Europe
  • 5.6.3 Asia Pacific
    • 5.6.3.1 China
    • 5.6.3.2 Japan
    • 5.6.3.3 India
    • 5.6.3.4 South Korea
    • 5.6.3.5 Australia
    • 5.6.3.6 Rest of Asia Pacific
  • 5.6.4 Middle East and Africa
    • 5.6.4.1 GCC
    • 5.6.4.2 South Africa
    • 5.6.4.3 Rest of Middle East and Africa
  • 5.6.5 South America
    • 5.6.5.1 Brazil
    • 5.6.5.2 Argentina
    • 5.6.5.3 Rest of South America

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Market Share Analysis
• 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
  • 6.3.1 Pfizer Inc.
  • 6.3.2 F. Hoffmann-La Roche Ltd
  • 6.3.3 Merck & Co. Inc.
  • 6.3.4 GlaxoSmithKline plc
  • 6.3.5 Teva Pharmaceutical Industries Ltd
  • 6.3.6 Baxter International
  • 6.3.7 Lupin Pharmaceuticals Inc.
  • 6.3.8 Macleods Pharmaceuticals Ltd
  • 6.3.9 Mankind Pharma
  • 6.3.10 Sun Pharmaceutical Industries Ltd
  • 6.3.11 AbbVie Inc.
  • 6.3.12 Bristol-Myers Squibb Company
  • 6.3.13 Eli Lilly and Company
  • 6.3.14 Sandoz (Novartis generics)
  • 6.3.15 Aurobindo Pharma Ltd
  • 6.3.16 Hikma Pharmaceuticals plc
  • 6.3.17 Fresenius Kabi
  • 6.3.18 Cipla Ltd
  • 6.3.19 Shionogi & Co., Ltd
  • 6.3.20 Zydus Lifesciences Ltd

7 Market Opportunities & Future Outlook

• 7.1 White-space & Unmet-Need Assessment