항이뇨제 : 시장 점유율 분석, 업계 동향 및 통계, 성장 예측(2026-2031년)

According to Mordor Intelligence, the antidiuretic drugs market size is projected to be USD 1.23 billion in 2025, USD 1.32 billion in 2026, and reach USD 1.99 billion by 2031, growing at a CAGR of 8.45% from 2026 to 2031.

This report is Segmented by Drug Type (Desmopressin, Vasopressin, Terlipressin, Lypressin, Others), Route of Administration (Oral, Intranasal, Injectable, IV, SC/IM), Indication (Central DI, PNE, Nocturia, Hemophilia A, Vasodilatory Shock, Others), End User (Hospitals, Specialty Clinics, Homecare), and Geography (North America, Europe, Asia-Pacific, MEA, South America). Forecasts in Terms of Value (USD).

Global Antidiuretic Drugs Market Trends and Insights

Higher Diagnosis Of AVP-Deficiency Disorders

Higher diagnosis is expanding the treatable pool in the antidiuretic drugs market. The change in clinical language from central diabetes insipidus to arginine vasopressin deficiency has sharpened diagnostic focus and reduced confusion in endocrine practice, which is improving case recognition in regular care pathways. A 2025 study in The Lancet Diabetes & Endocrinology developed and validated a basal clinical probability score that combined plasma sodium, osmolality, copeptin, and symptom features, and it diagnosed AVP-D in 75% of patients without dynamic stimulation testing. AVP-D remains a low-prevalence condition, yet real-world case capture is still below epidemiological expectations, so each upgrade in diagnostic protocol can directly widen the treated base for desmopressin use in the antidiuretic drugs market. Faster diagnosis also changes the care path because patients can move to treatment earlier, which increases treated patient-days over a full year. This helps the antidiuretic drugs market build growth from better identification, not only from a rise in disease prevalence.

Aging-Linked Nocturia Burden

Aging-linked nocturia is a major source of expansion for the antidiuretic drugs market. A 2024 review in Tzu Chi Medical Journal reported that nocturia prevalence exceeds 50% in adults older than 80, which shows how strongly demand is tied to population aging. The same review noted that direct healthcare costs tied to nocturia-related falls and injuries in the United States reached USD 1.5 billion annually, which keeps the condition visible to health systems and prescribers. This demand driver is stronger than a simple volume effect because older populations generate a repeat need for monitoring, follow-up, and long-term therapy decisions around nocturnal polyuria. As Japan and South Korea continue to age, primary care and urology settings are likely to record more formal nocturia diagnoses instead of treating the condition as an unstructured quality-of-life complaint. That shift gives the antidiuretic drugs market a broader referral base and a steadier prescription flow outside specialist endocrine centers.

Hyponatremia Monitoring Burden And Boxed Warnings

Hyponatremia monitoring remains the clearest brake on the antidiuretic drugs market. The FDA boxed warning for desmopressin acetate requires serum sodium to be normal before treatment starts, then checked within 7 days, at around 1 month, and periodically after that. The label also calls for closer observation in people aged 65 or older and in patients whose clinical profile raises sodium-related risk, which makes routine prescribing more cautious in older populations. This is a meaningful commercial issue because the same elderly patients who carry higher safety concerns also represent the most active nocturia population. Prescribers therefore face a clear tradeoff between symptom relief and the follow-up burden that safe treatment requires. Until monitoring becomes easier or confidence improves in lower-risk patient selection, this safety framework will keep part of the antidiuretic drugs market from converting awareness into prescriptions.

Other drivers and restraints analyzed in the detailed report include:

1. Generic Launches Expanding Access
2. Septic Shock Guideline Support For Vasopressin
3. Vasopressin Injection Shortages And Back-Order Risk

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Desmopressin accounted for 48.91% of the market in 2025 and remained the clear leader by drug type. That lead reflects its use across AVP-D, primary nocturnal enuresis, nocturia, nocturnal polyuria, and selected bleeding-related settings, which gives it a wider clinical base than competing classes. It also remains the best-established chronic therapy option in the antidiuretic drugs market because endocrinology and urology pathways are already built around it. Its V2 receptor selectivity keeps the therapeutic focus on antidiuretic action without the pressor effect seen with native vasopressin, which supports its long-standing role in routine care. The class still benefits from broad familiarity among specialists, general practitioners, and hospital teams, and that familiarity reduces switching pressure when new products arrive.

Lypressin is projected to grow at 8.84% CAGR through 2031, which makes it the fastest-growing drug type in this antidiuretic drugs market. Its growth is coming from a small base, yet it is gaining attention in narrower patient cohorts where nasal delivery and tolerability considerations shape treatment choice more heavily. Vasopressin continues to command meaningful hospital revenue because septic shock protocols still support its use in critical care and keep institutional purchasing active. Terlipressin now faces a more limited role in this specific therapeutic setting after the 2026 international sepsis guidance recommended against it for septic shock. The rest of the category remains small, but the user-supplied evidence shows that the antidiuretic drugs industry is not standing still and is still open to niche reformulation strategies. Eton's desmopressin oral solution program, which reached FDA filing acceptance in 2025, shows how companies are still trying to defend focused subsegments even as the core tablet business faces generic pressure.

Oral formulations held 39.57% of the antidiuretic drugs market size in 2025, which kept this route in the leading position. That leadership came from the practical fit of tablets and sublingual products in chronic AVP-D and nocturia management, where long-term adherence matters more than acute administration speed. Oral use also matches the shift of the antidiuretic drugs market toward home-based and outpatient care because it removes the need for regular clinical supervision in stable patients. The waterless convenience of oral disintegrating formats has been especially useful in older populations, where nighttime dosing patterns and fluid timing matter. This route, therefore, keeps the commercial center of gravity tied to convenience, patient routine, and refill continuity.

Injectables are projected to expand at 8.52% CAGR through 2031, making them the fastest-growing route in the antidiuretic drugs market. The main reason is stronger hospital demand for vasopressin products that can fit ICU protocols and procurement cycles with lower preparation burden. Ready-to-use presentations are particularly attractive because they reduce compounding steps, help lower medication error risk, and fit high-volume critical care settings more smoothly. Intranasal desmopressin remains clinically important for selected patients, but supply restoration has taken time after the earlier global recall tied to packaging tightness issues. Ferring said it submitted a variation to European regulators in November 2024 and planned a U.S. submission in Q2 2025 as part of that restoration process. Subcutaneous and intramuscular presentations remain smaller in commercial terms, yet they still matter in perioperative care and ICU transitions where route flexibility is clinically necessary.

Geography Analysis

North America held 38.43% of the market in 2025, which made it the largest regional base. The United States remains the core revenue center because it combines advanced ICU infrastructure, strong AVP-D diagnostic capacity, and active generic approvals across both oral and injectable products. The FDA's calendar year 2024 shortage report recorded 15 new drug shortages, the lowest level in a decade, yet vasopressin injection still remained on the active shortage list. That combination of strong demand and uneven supply creates a market where availability can matter as much as price for hospital customers. Canada followed a similar pattern and authorized the temporary importation of U.S.-authorized vasopressin injection in March 2026 to address a domestic supply shortfall for critical care patients. These events show that North America remains the most commercially important part of the antidiuretic drugs market, but also one of the most operationally sensitive.

Europe is the second-largest regional cluster in the antidiuretic drugs market and remains shaped by generic desmopressin competition and strict post-marketing surveillance. Ferring reported that Minirin sales declined 6% at constant exchange rates in 2024, partly because of generic entry in Western Europe and Canada. Germany and the UK stand out as high-value markets because they combine mature endocrine care with strong ICU vasopressin utilization. The Society for Endocrinology's clinical guidance has helped standardize inpatient AVP-D management and has supported more consistent prescribing and monitoring across NHS practice.

Asia-Pacific is projected to grow at 9.85% CAGR through 2031, making it the fastest-growing region in the antidiuretic drugs market. The region is benefiting from population aging, wider insurance access in parts of the region, and a stronger regional manufacturing base for generic medicines. Japan remains the most advanced country market in Asia-Pacific because aging is deepest there, and clinical guidance formally supports desmopressin as standard treatment for central DI. In January 2025, Kissei announced that its domestic sales partnership with Ferring for Minirin Melt and desmopressin preparations in Japan would end on March 31, 2025, after which Ferring would assume sole promotion responsibility. China and India are still earlier in penetration terms, but hospital expansion and rising healthcare spending are widening the treated pool over time. The Middle East, Africa, and South America remain smaller regional positions, yet critical care investment and broader reimbursement for rare endocrine disorders should keep incremental demand moving upward across the antidiuretic drugs market.

1. American Regent
2. Amneal Pharmaceuticals
3. Amphastar Pharmaceuticals
4. Apotex
5. Aurobindo Pharma Ltd.
6. Baxter
7. Caplin Steriles Limited
8. Civica, Inc.
9. Dr. Reddy's Laboratories Ltd.
10. Eugia US LLC
11. Ferring Pharmaceuticals
12. Fresenius
13. GLAND PHARMA
14. Glenmark Pharmaceuticals
15. Par Health, Inc.
16. Pharmascience
17. Sandoz Canada Incorporated
18. Sun Pharmaceuticals Industries
19. Teva Pharmaceutical Industries
20. Zydus Pharmaceuticals (USA) Inc.

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support

TABLE OF CONTENTS

1 Introduction

• 1.1 Study Assumptions & Market Definition
• 1.2 Scope of the Study

2 Research Methodology

3 Executive Summary

4 Market Landscape

• 4.1 Market Overview
• 4.2 Market Drivers
  • 4.2.1 Higher Diagnosis of AVP-Deficiency Disorders
  • 4.2.2 Aging-Linked Nocturia Burden
  • 4.2.3 Generic Launches Expanding Access
  • 4.2.4 Septic Shock Guideline Support for Vasopressin
  • 4.2.5 Post-Pituitary Surgery AVP-Deficiency Case Capture
  • 4.2.6 Copeptin-Led Diagnostic Upgrade
• 4.3 Market Restraints
  • 4.3.1 Hyponatremia Monitoring Burden and Boxed Warnings
  • 4.3.2 Limited Affordability in Chronic-Use Markets
  • 4.3.3 Vasopressin Injection Shortages and Back-Order Risk
  • 4.3.4 Route-Specific Adherence and Administration Frictions
• 4.4 Value / Supply-Chain Analysis
• 4.5 Regulatory Landscape
• 4.6 Technological Outlook
• 4.7 Porter's Five Forces Analysis
  • 4.7.1 Threat of New Entrants
  • 4.7.2 Bargaining Power of Suppliers
  • 4.7.3 Bargaining Power of Buyers
  • 4.7.4 Threat of Substitutes
  • 4.7.5 Industry Rivalry

5 Market Size & Growth Forecasts

• 5.1 By Drug Type
  • 5.1.1 Desmopressin
  • 5.1.2 Vasopressin
  • 5.1.3 Terlipressin
  • 5.1.4 Lypressin
  • 5.1.5 Other Drug Type
• 5.2 By Route of Administration
  • 5.2.1 Oral
    • 5.2.1.1 Tablets
    • 5.2.1.2 Oral lyophilisates / sublingual tablets
  • 5.2.2 Intranasal
    • 5.2.2.1 Metered nasal sprays
    • 5.2.2.2 Nasal solutions / drops
  • 5.2.3 Injectable
  • 5.2.4 Intravenous
  • 5.2.5 Subcutaneous / intramuscular
• 5.3 By Indication
  • 5.3.1 Central Diabetes Insipidus
  • 5.3.2 Primary Nocturnal Enuresis
  • 5.3.3 Nocturia / Nocturnal Polyuria
  • 5.3.4 Hemophilia A and von Willebrand Disease Type 1
  • 5.3.5 Vasodilatory Shock
  • 5.3.6 Temporary Postoperative Polyuria / Polydipsia
• 5.4 By End User
  • 5.4.1 Hospitals
  • 5.4.2 Specialty Clinics
  • 5.4.3 Endocrinology Clinics
  • 5.4.4 Urology Clinics
  • 5.4.5 Hematology Clinics
  • 5.4.6 Homecare Settings
• 5.5 By Geography
  • 5.5.1 North America
    • 5.5.1.1 United States
    • 5.5.1.2 Canada
    • 5.5.1.3 Mexico
  • 5.5.2 Europe
    • 5.5.2.1 Germany
    • 5.5.2.2 United Kingdom
    • 5.5.2.3 France
    • 5.5.2.4 Italy
    • 5.5.2.5 Spain
    • 5.5.2.6 Rest of Europe
  • 5.5.3 Asia-Pacific
    • 5.5.3.1 China
    • 5.5.3.2 Japan
    • 5.5.3.3 India
    • 5.5.3.4 Australia
    • 5.5.3.5 South Korea
    • 5.5.3.6 Rest of Asia-Pacific
  • 5.5.4 Middle East & Africa
    • 5.5.4.1 GCC
    • 5.5.4.2 South Africa
    • 5.5.4.3 Rest of Middle East & Africa
  • 5.5.5 South America
    • 5.5.5.1 Brazil
    • 5.5.5.2 Argentina
    • 5.5.5.3 Rest of South America

6 Competitive Landscape

• 6.1 Market Concentration
• 6.2 Market Share Analysis
• 6.3 Company Profiles (includes Global level Overview, Market-level Overview, Core Segments, Financials, Strategic Information, Market Rank/Share, Products & Services, Recent Developments)
  • 6.3.1 American Regent, Inc.
  • 6.3.2 Amneal Pharmaceuticals, Inc.
  • 6.3.3 Amphastar Pharmaceuticals, Inc.
  • 6.3.4 Apotex Inc.
  • 6.3.5 Aurobindo Pharma Ltd.
  • 6.3.6 Baxter International Inc.
  • 6.3.7 Caplin Steriles Limited
  • 6.3.8 Civica, Inc.
  • 6.3.9 Dr. Reddy's Laboratories Ltd.
  • 6.3.10 Eugia US LLC
  • 6.3.11 Ferring Pharmaceuticals
  • 6.3.12 Fresenius Kabi
  • 6.3.13 Gland Pharma Limited
  • 6.3.14 Glenmark Pharmaceuticals Inc.
  • 6.3.15 Par Health, Inc.
  • 6.3.16 Pharmascience Inc.
  • 6.3.17 Sandoz Canada Incorporated
  • 6.3.18 Sun Pharmaceutical Industries Ltd.
  • 6.3.19 Teva Pharmaceutical Industries Ltd.
  • 6.3.20 Zydus Pharmaceuticals (USA) Inc.

7 Market Opportunities & Future Outlook

• 7.1 White-space & Unmet-need Assessment