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시장보고서
상품코드
2117966
글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 규모, 대상 환자층, 경쟁 구도 및 시장 예측(2036년)Glucagon-like Peptide-1 (GLP-1) Agonists Market Size, Target Population, Competitive Landscape & Market Forecast - 2036 |
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DelveInsight
주요 7개국(G7)의 글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 규모 및 전망
글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 보고서는 표준 치료, 임상 실무 및 진화하는 치료 알고리즘을 포함한 현재 치료 시장 상황에 대한 종합적인 분석을 제공합니다. 본 보고서는 GLP-1 작용제에 대한 환자 부담 동향, 매출 및 시장 점유율 동향, 정점 시 환자 점유율 및 치료 도입 현황 분석을 평가함과 동시에, 전 세계 각 지역의 시장 규모에 대한 상세한 평가 및 성장률 예측(과거 데이터 및 2022-2036년 예측)을 제공합니다. 본 보고서는 GLP-1 작용제 분야의 주요 미충족 의료 수요를 부각시키고, 경쟁 환경 및 임상 상황을 분석하여 고부가가치 기회를 규명하는 한편, 향후 시장 성장 가능성에 대한 명확한 전망을 제시합니다.
GLP-1 수용체 작용제와 관련된 적응증의 규명이 진행되고 있다는 점
GLP-1 수용체 작용제(GLP-1 RA)를 통한 치료가 가능한 대사성 및 심대사성 질환의 규명 및 치료는, 질병 부담의 증가, 임상적 이해의 심화, 그리고 혈당 조절 이외의 이점에 관한 증거의 축적을 배경으로 확대되고 있습니다. 2형 당뇨병과 비만이 여전히 주요 적응증인 반면, 증거의 축적과 규제 당국의 승인 확대에 따라 심혈관질환, 만성 신장질환, 폐쇄성 수면 무호흡 증후군, 그리고 대사 기능 장애 관련 지방간염(MASH)에 대한 적응증 기회가 넓어지고 있습니다.
GLP-1 수용체 작용제의 확대되는 기회
GLP-1 수용체 작용제의 임상적 유효성에 대한 근거가 강화되고, 혈당 조절 및 체중 감량에 있어 뛰어난 유효성이 확인되며 적응증이 확대됨에 따라, 이 약물군에는 큰 비즈니스 기회가 생겨나고 있습니다. 경구 제제, 듀얼/멀티 수용체 작용제, 그리고 차세대 인크레틴 요법의 개발로 인해 대상 환자층이 더욱 확대되고, GLP-1 시장 내 경쟁이 격화될 것으로 예상됩니다.
글루카곤 유사 펩타이드-1(GLP-1) 작용제의 개요
GLP-1은 당 대사와 식욕 조절에 중요한 역할을 하는 인크레틴 호르몬입니다. GLP-1 수용체 작용제는 혈당 의존성 인슐린 분비를 촉진하고, 글루카곤 분비를 억제하며, 위 내용물의 배출을 지연시키고, 포만감을 높임으로써 내인성 GLP-1의 작용을 모방합니다. 이러한 작용을 통해 혈당 조절이 개선되고, 식사 섭취량 및 체중이 감소합니다.
이러한 대사 작용을 통해 GLP-1은 2형 당뇨병 및 비만에 대한 중요한 치료제군으로 자리매김하고 있으며, 심혈관질환, 만성 신장질환, 폐쇄성 수면 무호흡 증후군 등의 질환에 대한 적용 범위도 확대되고 있습니다. 이중 및 다중 수용체 인크레틴 작용제의 개발에 더해, 경구 제제 및 지속형 제제의 개발로 인해 GLP-1 기반 치료법의 치료적 가능성과 대상 시장은 더욱 확대되고 있습니다.
글루카곤 유사 펩타이드-1(GLP-1) 작용제의 적응증
GLP-1 수용체 작용제는 단독의 진단 기준과는 관련이 없으나, 임상 평가에 근거하여 대사성 질환 관리에 사용됩니다. 환자의 적격성은 일반적으로 혈당 수치, HbA1c, 체질량 지수(BMI), 체중 및 체중과 관련된 동반 질환 등의 지표를 통해 평가됩니다. GLP-1 작용제는 주로 2형 당뇨병 및 비만 치료에 사용되지만, 관련 심혈관질환, 신장질환, 대사성 질환이 치료법 선택에 점점 더 큰 영향을 미치고 있습니다.
글루카곤 유사 펩타이드-1(GLP-1) 작용제를 이용한 치료
GLP-1 수용체 작용제 치료는 GLP-1 수용체를 활성화하는 데 중점을 두어, 혈당 조절, 식욕 조절 및 대사 건강 상태의 개선을 도모합니다. 이러한 치료법은 주로 2형 당뇨병과 비만에 사용되지만, 일부 약물은 심혈관질환, 신장질환 및 폐쇄성 수면 무호흡 증후군에 대한 적응증으로도 승인되었습니다. 대부분의 GLP-1 작용제는 혈당 의존성 인슐린 분비를 촉진하고, 글루카곤 분비를 억제하며, 위 내용물의 배출을 지연시켜 포만감을 높입니다. GIP/GLP-1 작용제와 같은 새로운 이중 작용제 및 다중 수용체 작용제는 혈당 조절과 체중 감소를 더욱 개선하기 위해 개발이 진행되고 있습니다.
글루카곤 유사 펩타이드-1(GLP-1) 작용제의 역학적 분석 및 예측에 관한 주요 조사 결과
GLP-1 수용체 작용제 시장은 2형 당뇨병(T2DM) 및 비만의 부담 증가, 인크레틴 계열 치료제의 사용 확대, 그리고 이러한 약물이 대사 및 심혈관계 전반에 미치는 광범위한 이점에 대한 인식 제고에 힘입어 강력한 성장을 유지할 것으로 예상됩니다. 시장은 기존의 혈당 강하 용도에서 만성 체중 관리 및 심혈관 대사 위험 감소로 점점 더 전환되고 있으며, 세마글루타이드와 틸제파티드가 주요 성장 동력으로 부상하고 있습니다.
세마글루티드는 당뇨병 및 비만 두 분야 모두에서 확립된 사용 실적, 주사제 및 경구제 두 가지 제형의 이용 가능성, 그리고 광범위한 임상적 증거를 바탕으로 현재 확고한 입지를 구축하고 있습니다. 한편, GIP/GLP-1 수용체 이중 작용제인 틸제파티드는 혈당 조절 및 체중 감소에 대한 강력한 효능으로 시장 점유율을 대폭 확대할 것으로 예상됩니다. 인도에서는 틸제파티드가 가장 빠르게 성장하는 제품 부문이 될 것으로 예측되지만, 매출액 면에서는 세마글루티드가 계속해서 1위 자리를 유지할 전망입니다. GLP-1 요법은 비만 성인에게 효과적인 선택지이지만, WHO는 의약품만으로는 불충분하다고 강조하고 있습니다. 비만 대책에는 보다 건강한 환경 조성, 고위험군에 대한 조기 개입, 그리고 평생에 걸친 환자 중심의 치료에 초점을 맞춘 다부문적 접근이 필요합니다.
또한, 적응증 확대, 의사의 처방 증가, 환자 인식 제고, 그리고 차세대 인크레틴 요법의 개발도 시장에 긍정적인 영향을 미칠 것으로 예상됩니다. 경구 제제에 대한 관심 증가는 편의성과 치료 수용성을 더욱 향상시킬 가능성이 있는 반면, 혁신적인 치료법과 저비용 대체 요법 간의 경쟁은 가격 책정 및 시장 접근성에 영향을 미칠 것으로 보입니다.
Glucagon-like peptide-1 (GLP-1) Agonist Market Size and Forecast in the 7MM
DelveInsight's 'Glucagon-like peptide-1 (GLP-1) Agonist - Target Population, Competitive Landscape, and Market Metadata-2036' report delivers an in-depth understanding of the GLP-1 agonist, historical and forecasted epidemiology, as well as the GLP-1 agonist market trends in the United States, EU4 (Germany, Spain, Italy, and France), the United Kingdom, and Japan.
The Glucagon-like peptide-1 (GLP-1) agonist market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates GLP-1 agonist patient burden trends, revenue and market share dynamics, peak patient share and therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in GLP-1 agonist and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.
Key Factors Driving the Glucagon-like peptide-1 (GLP-1) Agonist Market
Growing Identification of GLP-1 Receptor Agonist-Associated Indications
The identification and treatment of metabolic and cardiometabolic conditions amenable to GLP-1 receptor agonists (GLP-1 RAs) are expanding, driven by increasing disease burden, improved clinical understanding, and growing evidence of benefits beyond glycemic control. While type 2 diabetes and obesity remain the core indications, growing evidence and regulatory approvals are expanding opportunities into cardiovascular disease, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction-associated steatohepatitis (MASH).
Rising Opportunities in GLP-1 Receptor Agonists
Increasing clinical validation of GLP-1 receptor agonist, strong efficacy in glycemic control and weight reduction, and expanding indications are creating significant opportunities for the class. The development of oral formulations, dual/multi-receptor agonists, and next-generation incretin therapies is further expected to expand the addressable patient population and strengthen competition within the GLP-1 market.
Glucagon-like peptide-1 (GLP-1) Agonist Overview
GLP-1 is an incretin hormone that plays an important role in regulating glucose metabolism and appetite. GLP-1 receptor agonists mimic the effects of endogenous GLP-1 by enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and increasing satiety. These effects improve glycemic control and reduce food intake and body weight.
Due to their metabolic effects, GLP-1 have become an important therapeutic class for type 2 diabetes and obesity, with expanding applications in conditions such as cardiovascular disease, chronic kidney disease, and obstructive sleep apnea. The development of dual and multi-receptor incretin agonists, along with oral and longer-acting formulations, is further expanding the therapeutic potential and addressable market for GLP-1-based therapies.
Glucagon-like peptide-1 (GLP-1) Agonist Diagnosis
GLP-1 receptor agonists are not associated with a standalone diagnostic condition but are used to manage metabolic disorders based on clinical assessment. Patient eligibility is typically evaluated using measures such as blood glucose levels, HbA1c, body mass index (BMI), and weight-related comorbidities. GLP-1 agonists are primarily used in type 2 diabetes and obesity, with treatment selection increasingly influenced by associated cardiovascular, renal, and metabolic conditions.
Glucagon-like peptide-1 (GLP-1) Agonist Treatment
GLP-1 receptor agonist treatment focuses on activating the GLP-1 receptor to improve glucose regulation, appetite control, and metabolic health. These therapies are primarily used in type 2 diabetes and obesity, with some agents also approved for cardiovascular, renal, and obstructive sleep apnea indications. Most GLP-1 agonist enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and increase satiety. Newer dual and multi-receptor agonists, such as GIP/GLP-1 agonists, are being developed to provide greater improvements in glycemic control and weight reduction.
Glucagon-like peptide-1 (GLP-1) Agonist Unmet Needs
The section "unmet needs of Glucagon-like peptide-1 (GLP-1) Agonist Unmet Needs" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.
Comprehensive unmet needs insights in Glucagon-like peptide-1 (GLP-1) Agonist and their strategic implications are provided in the full report.
Key Findings from Glucagon-like peptide-1 (GLP-1) Agonist Epidemiological Analysis and Forecast
Glucagon-like peptide-1 (GLP-1) Agonist Drug Chapters & Competitive Analysis
The GLP-1 agonist drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the GLP-1 AGONIST treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the GLP-1 AGONIST therapeutics market.
Approved Therapy for Glucagon-like peptide-1 (GLP-1) Agonist
Orforglipron (FOUNDAYO): Eli Lilly
Orforglipron is a once-daily oral GLP-1 receptor agonist marketed by Eli Lilly under the brand FOUNDAYO and FDA approved in April 2026 for chronic weight management. It is indicated, in combination with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain long-term weight reduction in adults with obesity or adults with overweight with at least one weight-related comorbid condition. Unlike injectable GLP-1 therapies, FOUNDAYO can be taken once daily with or without food and without specific food or water restrictions.
Semaglutide (OZEMPIC/RYBELSUS/WEGOVY): Novo Nordisk
Semaglutide is a GLP-1 receptor agonist marketed by Novo Nordisk under different brand names with distinct FDA-approved indications.
OZEMPIC: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease.
RYBELSUS: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes who are at high risk for these events.
WEGOVY: Indicated, in combination with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain long-term weight reduction in adults and pediatric patients aged 12 years and older with obesity, and in adults with overweight in the presence of at least one weight-related comorbid condition.
WEGOVY is also indicated to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and obesity or overweight, and for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-advanced fibrosis (F2-F3) in adults. Novo Nordisk continues to be GLP-1 volume leader, with 58% market share.
Tirzepatide (MOUNJARO/ZEPBOUND): Eli Lilly
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist marketed by Eli Lilly under different brand names with distinct FDA-approved indications.
MOUNJARO: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
ZEPBOUND: Indicated, in combination with a reduced-calorie diet and increased physical activity, for chronic weight management in adults with an initial BMI of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition, such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea, or cardiovascular disease. ZEPBOUND sales reached USD 4.9 billion in Q2 2026, increasing by USD 1.5 billion from USD 3.4 billion in Q2 2025, representing approximately 44% year-over-year growth, driven by continued increases in US prescription volume and market share.
ZEPBOUND is also indicated for the treatment of moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Glucagon-like peptide-1 (GLP-1) Agonist Pipeline Analysis
CagriSema: Novo Nordisk
CagriSema, developed by Novo Nordisk, is a once-weekly subcutaneous fixed-dose combination of the long-acting amylin analogue cagrilintide (2.4 mg) and the GLP-1 receptor agonist semaglutide (2.4 mg), currently under investigation for weight management in adults with overweight or obesity.
Survodutide (BI 456906): Boehringer Ingelheim
Survodutide (BI 456906) is a GCGR/GLP1 dual agonist being developed by Boehringer Ingelheim. Both receptors are critical to controlling metabolic functions. The compound leverages the known effects of the natural gut hormone oxyntomodulin, which has been shown to decrease food intake and increase energy expenditure in humans as well as the established effects of GLP1 agonism on both glucose control and body weight. The drug is currently in Phase III.
Glucagon-like peptide-1 (GLP-1) Agonist Key Players, Market Leaders, and Emerging Companies
Glucagon-like peptide-1 (GLP-1) Agonist Key Players Drug Updates
Drug Class Insights
The GLP-1 receptor agonist market is expected to maintain strong growth, supported by the increasing burden of type 2 diabetes mellitus (T2DM) and obesity, expanding use of incretin-based therapies, and growing recognition of their broader metabolic and cardiovascular benefits. The market is increasingly shifting from traditional glucose-lowering applications toward chronic weight management and cardiometabolic risk reduction, with semaglutide and tirzepatide emerging as key growth drivers.
Semaglutide currently holds a strong position because of its established use across diabetes and obesity, availability in both injectable and oral formulations, and broad clinical evidence. Meanwhile, tirzepatide, a dual GIP/GLP-1 receptor agonist, is expected to gain significant market share due to its strong efficacy in glycemic control and weight reduction. In India, tirzepatide is projected to be the fastest-growing product segment, while semaglutide remains the leading product by revenue. GLP-1 therapies offer an effective option for adults with obesity, but WHO emphasizes that medicines alone are insufficient. Obesity requires a multisectoral approach focused on healthier environments, early intervention for high-risk individuals, and lifelong, person-centred care.
The market is also expected to benefit from expanding indications, increasing physician adoption, improved patient awareness, and the development of next-generation incretin therapies. Growing interest in oral formulations could further improve convenience and treatment uptake, while competition between innovative therapies and lower-cost alternatives is likely to influence pricing and market access.
Drug Class/Insights into Leading Emerging and Marketed Therapies in Glucagon-like peptide-1 (GLP-1) Agonist (2022-2036 Forecast)
The current drug class/insights into leading emerging and marketed therapies in GLP-1 receptor agonists are centered on incretin-based metabolic modulation, primarily through activation of the GLP-1 receptor to improve glycemic control, reduce appetite, delay gastric emptying, and promote weight loss.
Glucagon-like peptide-1 (GLP-1) Agonist Drug Uptake
This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the GLP-1 AGONIST market's uptake by drugs, patient uptake by therapy, and sales of each drug. The uptake analysis evaluates the potential adoption of GLP-1 therapies based on clinical efficacy, safety and tolerability, treatment persistence, dosing convenience, patient and physician acceptance, pricing and reimbursement, competitive dynamics, and expansion into additional indications. These factors are expected to influence the speed of patient uptake, treatment penetration, and sales growth of individual therapies throughout the forecast period.
Glucagon-like peptide-1 (GLP-1) Agonist Therapies Price Scenario & Trends
Pricing and analogue assessment of GLP-1 agonist therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.
Further details are provided in the final report....
Industry Experts and Physician Views for Glucagon-like peptide-1 (GLP-1) Agonist
To keep up with GLP-1 agonist market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on GLP-1 agonist emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in GLP-1 agonist, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.
DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 6+ KOLs in the 7MM. Centers such as the University of North Carolina at Chapel Hill, the Berlin Institute of Health at Charite, and the University of Nottingham, etc. were contacted. Their opinion helps understand and validate current and emerging GLP-1 agonist therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in GLP-1 agonist.
Qualitative Analysis: SWOT and Conjoint Analysis
We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.
In the SWOT analysis of GLP-1 agonist, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.
Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Insights