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글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 규모, 대상 환자층, 경쟁 구도 및 시장 예측(2036년)

Glucagon-like Peptide-1 (GLP-1) Agonists Market Size, Target Population, Competitive Landscape & Market Forecast - 2036

발행일: | 리서치사: 구분자 DelveInsight | 페이지 정보: 영문 120 Pages | 배송안내 : 2-10일 (영업일 기준)

    
    
    




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글루카곤 유사 펩타이드-1(GLP-1) 작용제에 대한 인사이트 및 동향

  • GLP-1 작용제는 주로 2형 당뇨병 치료에 사용되며, 때로는 체중 관리에도 활용되는 약물의 일종입니다. 이 약물은 혈중 혈당 수치를 조절하는 역할을 하는 천연 호르몬인 GLP-1의 작용을 모방함으로써 효과를 발휘합니다.
  • GLP-1 시장은 2형 당뇨병(T2DM)에 그치지 않고 비만 및 더 광범위한 대사 질환과 심혈관질환의 적응증 영역으로 빠르게 확대되고 있으며, 2024년 중반 시점에서 Eli Lilly와 Novo Nordisk가 시장을 독점하며 약 94%의 시장 점유율을 차지하고 있습니다.
  • GLP-1 시장은 경구 제제, 이중 및 삼중 표적 작용제, 그리고 전 세계 시장에서 제네릭 의약품 및 바이오시밀러와의 경쟁이 예상되는 향후 특허 만료를 배경으로, 경쟁 구도가 더욱 치열한 시장 구조로 변화하고 있습니다.
  • 2026년 4월 미국에서 승인된 일라이 릴리의 올포글리프론(FOUNDAYO)은 식사나 수분 섭취에 엄격한 제한이 필요 없는, 만성적인 체중 관리를 목적으로 한 최초의 경구용 GLP-1 제제가 되었습니다. 한편, 노보 노르디스크의 세마글루타이드(WEGOVY 정)는 2026년 중반까지 전 세계 처방 건수가 100만 건을 돌파하며, 초기 단계의 경구용 비만 치료제 시장의 약 90%를 차지했습니다.
  • 2025년, 릴리(Lilly)사의 틸제파티드 제품군은 강력한 성장세를 보이며, ‘MOUNJARO’가 229억 7,000만 달러,‘ZEPBOUND’는 135억 4,000만 달러, 합계 365억 1,000만 달러의 매출을 기록했습니다. 미국 내 매출은 ‘MOUNJARO’가 53%, ‘ZEPBOUND’가 174% 증가했으나, 견조한 수요에 힘입은 반면, 실현 가격 하락이 이익의 일부를 상쇄했습니다.
  • 미국당뇨병학회(ADA)의 2026년 지침에서는 GLP-1 작용제를 혈당 조절에 그치지 않는 심혈관 대사 치료제로 규정하며, A1C 수치나 메트포르민 사용 여부와 관계없이 ASCVD 또는 ASCVD 고위험군,심부전, 혹은 만성 신장질환(CKD)을 동반한 2형 당뇨병(T2DM) 환자에게 사용을 권장하고 있습니다. 이에 따라 대상 시장은 심혈관질환, 심부전, 신장 위험 감소로 확대되는 한편, 저혈당 위험이 낮다는 특성이 고위험 환자에서의 사용을 뒷받침하고 있습니다.
  • GLP-1 제제 시장은 엑세나티드(BYETTA)나 릴라글루티드(VICTOZA)와 같은 1세대 약물에서 세마글루티드(OZEMPIC/WEGOVY/RYBELSUS),GIP/GLP-1 이중 작용제인 틸제파티드(MOUNJARO/ZEPBOUND), 그리고 경구용 GLP-1 작용제인 올포글리프론(FOUNDAYO)과 같은 새로운 치료법으로 진화해 왔습니다. 이러한 진보로 인해 혈당 조절 및 체중 관리를 위한 치료 선택지가 확대되었습니다.
  • GLP-1 파이프라인에는 레타토르티드, CagriSema, 살보두티드 등 유망한 후보 약물이 포함되어 있습니다. 차세대 다중 수용체 작용제 및 상호 보완적인 대사 경로를 활용함으로써, 이러한 후보 약물들은 1세대 GLP-1 수용체 작용제보다 우수한 체중 감량 효과와 더 광범위한 심혈관 및 대사상의 이점을 입증하고 있으며,유효성의 기준을 재정의하고, 점점 더 다양해지는 환자 집단에 대한 치료 범위를 확대할 수 있는 위치에 있습니다.

주요 7개국(G7)의 글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 규모 및 전망

글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장 보고서는 표준 치료, 임상 실무 및 진화하는 치료 알고리즘을 포함한 현재 치료 시장 상황에 대한 종합적인 분석을 제공합니다. 본 보고서는 GLP-1 작용제에 대한 환자 부담 동향, 매출 및 시장 점유율 동향, 정점 시 환자 점유율 및 치료 도입 현황 분석을 평가함과 동시에, 전 세계 각 지역의 시장 규모에 대한 상세한 평가 및 성장률 예측(과거 데이터 및 2022-2036년 예측)을 제공합니다. 본 보고서는 GLP-1 작용제 분야의 주요 미충족 의료 수요를 부각시키고, 경쟁 환경 및 임상 상황을 분석하여 고부가가치 기회를 규명하는 한편, 향후 시장 성장 가능성에 대한 명확한 전망을 제시합니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장을 견인하는 주요 요인

GLP-1 수용체 작용제와 관련된 적응증의 규명이 진행되고 있다는 점

GLP-1 수용체 작용제(GLP-1 RA)를 통한 치료가 가능한 대사성 및 심대사성 질환의 규명 및 치료는, 질병 부담의 증가, 임상적 이해의 심화, 그리고 혈당 조절 이외의 이점에 관한 증거의 축적을 배경으로 확대되고 있습니다. 2형 당뇨병과 비만이 여전히 주요 적응증인 반면, 증거의 축적과 규제 당국의 승인 확대에 따라 심혈관질환, 만성 신장질환, 폐쇄성 수면 무호흡 증후군, 그리고 대사 기능 장애 관련 지방간염(MASH)에 대한 적응증 기회가 넓어지고 있습니다.

GLP-1 수용체 작용제의 확대되는 기회

GLP-1 수용체 작용제의 임상적 유효성에 대한 근거가 강화되고, 혈당 조절 및 체중 감량에 있어 뛰어난 유효성이 확인되며 적응증이 확대됨에 따라, 이 약물군에는 큰 비즈니스 기회가 생겨나고 있습니다. 경구 제제, 듀얼/멀티 수용체 작용제, 그리고 차세대 인크레틴 요법의 개발로 인해 대상 환자층이 더욱 확대되고, GLP-1 시장 내 경쟁이 격화될 것으로 예상됩니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제에 대한 이해와 치료 알고리즘

글루카곤 유사 펩타이드-1(GLP-1) 작용제의 개요

GLP-1은 당 대사와 식욕 조절에 중요한 역할을 하는 인크레틴 호르몬입니다. GLP-1 수용체 작용제는 혈당 의존성 인슐린 분비를 촉진하고, 글루카곤 분비를 억제하며, 위 내용물의 배출을 지연시키고, 포만감을 높임으로써 내인성 GLP-1의 작용을 모방합니다. 이러한 작용을 통해 혈당 조절이 개선되고, 식사 섭취량 및 체중이 감소합니다.

이러한 대사 작용을 통해 GLP-1은 2형 당뇨병 및 비만에 대한 중요한 치료제군으로 자리매김하고 있으며, 심혈관질환, 만성 신장질환, 폐쇄성 수면 무호흡 증후군 등의 질환에 대한 적용 범위도 확대되고 있습니다. 이중 및 다중 수용체 인크레틴 작용제의 개발에 더해, 경구 제제 및 지속형 제제의 개발로 인해 GLP-1 기반 치료법의 치료적 가능성과 대상 시장은 더욱 확대되고 있습니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제의 적응증

GLP-1 수용체 작용제는 단독의 진단 기준과는 관련이 없으나, 임상 평가에 근거하여 대사성 질환 관리에 사용됩니다. 환자의 적격성은 일반적으로 혈당 수치, HbA1c, 체질량 지수(BMI), 체중 및 체중과 관련된 동반 질환 등의 지표를 통해 평가됩니다. GLP-1 작용제는 주로 2형 당뇨병 및 비만 치료에 사용되지만, 관련 심혈관질환, 신장질환, 대사성 질환이 치료법 선택에 점점 더 큰 영향을 미치고 있습니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제를 이용한 치료

GLP-1 수용체 작용제 치료는 GLP-1 수용체를 활성화하는 데 중점을 두어, 혈당 조절, 식욕 조절 및 대사 건강 상태의 개선을 도모합니다. 이러한 치료법은 주로 2형 당뇨병과 비만에 사용되지만, 일부 약물은 심혈관질환, 신장질환 및 폐쇄성 수면 무호흡 증후군에 대한 적응증으로도 승인되었습니다. 대부분의 GLP-1 작용제는 혈당 의존성 인슐린 분비를 촉진하고, 글루카곤 분비를 억제하며, 위 내용물의 배출을 지연시켜 포만감을 높입니다. GIP/GLP-1 작용제와 같은 새로운 이중 작용제 및 다중 수용체 작용제는 혈당 조절과 체중 감소를 더욱 개선하기 위해 개발이 진행되고 있습니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제의 역학

글루카곤 유사 펩타이드-1(GLP-1) 작용제의 역학적 분석 및 예측에 관한 주요 조사 결과

  • 2형 당뇨병은 전 세계 당뇨병 사례의 85% 이상을 차지합니다. 2021년 기준으로 약 5억 3,700만 명의 성인이 당뇨병을 앓고 있으며, 미국에서는 매년 약 140만 명의 신규 당뇨병 환자가 진단되고 있습니다.
  • 2024년에 실시된 연구에 따르면, GLP-1 작용제의 12개월간 복용 중단률은 전체적으로 36.5%로 추정되며, 2형 당뇨병 환자에 비해 비만만 있는 환자에서 중단률이 높은 것으로 나타났습니다. 복용 중단율 상승과 관련된 요인으로는 젊은 연령대, 여성인 경우, 그리고 본인 부담금이 높은 점이 꼽혔습니다.
  • 2차 분석에 따르면, 주 1회 투여하는 GLP-1 수용체 작용제의 사용은 치료 전 위 초음파 검사에서 확인된 위 잔류 내용물의 증가율과 독립적으로 관련이 있었으며, 그 유병률은 30.5% 더 높았습니다. 이는 마취 중 흡인의 주요 위험 요인입니다.

글루카곤 유사 펩타이드-1(GLP-1) 작용제 시장의 전망

GLP-1 수용체 작용제 시장은 2형 당뇨병(T2DM) 및 비만의 부담 증가, 인크레틴 계열 치료제의 사용 확대, 그리고 이러한 약물이 대사 및 심혈관계 전반에 미치는 광범위한 이점에 대한 인식 제고에 힘입어 강력한 성장을 유지할 것으로 예상됩니다. 시장은 기존의 혈당 강하 용도에서 만성 체중 관리 및 심혈관 대사 위험 감소로 점점 더 전환되고 있으며, 세마글루타이드와 틸제파티드가 주요 성장 동력으로 부상하고 있습니다.

세마글루티드는 당뇨병 및 비만 두 분야 모두에서 확립된 사용 실적, 주사제 및 경구제 두 가지 제형의 이용 가능성, 그리고 광범위한 임상적 증거를 바탕으로 현재 확고한 입지를 구축하고 있습니다. 한편, GIP/GLP-1 수용체 이중 작용제인 틸제파티드는 혈당 조절 및 체중 감소에 대한 강력한 효능으로 시장 점유율을 대폭 확대할 것으로 예상됩니다. 인도에서는 틸제파티드가 가장 빠르게 성장하는 제품 부문이 될 것으로 예측되지만, 매출액 면에서는 세마글루티드가 계속해서 1위 자리를 유지할 전망입니다. GLP-1 요법은 비만 성인에게 효과적인 선택지이지만, WHO는 의약품만으로는 불충분하다고 강조하고 있습니다. 비만 대책에는 보다 건강한 환경 조성, 고위험군에 대한 조기 개입, 그리고 평생에 걸친 환자 중심의 치료에 초점을 맞춘 다부문적 접근이 필요합니다.

또한, 적응증 확대, 의사의 처방 증가, 환자 인식 제고, 그리고 차세대 인크레틴 요법의 개발도 시장에 긍정적인 영향을 미칠 것으로 예상됩니다. 경구 제제에 대한 관심 증가는 편의성과 치료 수용성을 더욱 향상시킬 가능성이 있는 반면, 혁신적인 치료법과 저비용 대체 요법 간의 경쟁은 가격 책정 및 시장 접근성에 영향을 미칠 것으로 보입니다.

  • GLP-1 수용체 작용제: 릴라글루티드, 듀라글루티드, 엑세나티드, 릭시세나티드, 세마글루티드 등의 시판 치료제는 2형 당뇨병 관리에 대해 승인되었으며, 세마글루티드와 릴라글루티드는 만성 체중 관리에도 승인되었습니다. 이러한 치료제를 통해 GLP-1 수용체 활성화가 혈당 조절 개선 및 체중 감소를 위한 효과적인 접근법임이 입증되었습니다.
  • 이중/다중 수용체 인크레틴 작용제: GIP/GLP-1 수용체 이중 작용제인 틸제파티드는 선택적 GLP-1 수용체 활성화를 뛰어넘는 큰 진보를 나타냅니다. 혈당 조절과 체중 감소에 현저한 개선을 가져와, 기존의 GLP-1 수용체 작용제(RA)에 대한 중요한 경쟁 약물이 되고 있습니다. 또한 체중 감량 효과와 대사 개선 효과를 높이기 위해 그 밖의 차세대 다중 작용제 개발도 진행되고 있습니다.
  • 차세대 GLP-1 요법: 현재 개발 중인 파이프라인에는 경구용 GLP-1 수용체 작용제, 지속형 제제, 병용요법 및 다중 수용체 작용제가 포함되어 있으며, 편의성, 유효성, 내약성 및 치료 순응도 향상을 목표로 하고 있습니다. 이러한 접근 방식을 통해 인크레틴 요법의 적용 범위가 당뇨병과 비만에 그치지 않고, 보다 광범위한 심혈관 및 대사 질환으로 확대될 것으로 기대됩니다.

자주 묻는 질문

  • GLP-1 작용제 시장의 주요 기업은 어디인가요?
  • GLP-1 작용제의 주요 적응증은 무엇인가요?
  • GLP-1 작용제 시장의 성장 요인은 무엇인가요?
  • 2026년 GLP-1 작용제 시장의 전망은 어떻게 되나요?
  • GLP-1 작용제의 복용 중단률은 어떻게 되나요?
  • GLP-1 작용제의 치료 알고리즘은 어떻게 구성되나요?
  • GLP-1 작용제의 시장 규모는 어떻게 되나요?

목차

제1장 주요 인사이트

제2장 소개

제3장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : 주요 요약

제4장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : 시장 개요

제5장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : 역학 및 시장 조사 방법

제6장 주요 사건

제7장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 배경과 개요

제8장 주요 7개국의 글루카곤 유사 펩타이드-1(GLP-1) 작용제 역학적 상황과 환자 인구

제9장 환자 경과

제10장 시판 치료제

제11장 새로운 치료법

제12장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : 주요 7개국 분석

제13장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : 미충족 수요

제14장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : SWOT 분석

제15장 글루카곤 유사 펩타이드-1(GLP-1) 작용제 : KOL의 견해

제16장 시장 진입 및 보험 상환

제17장 부록

제18장 DelveInsight의 서비스 내용

제19장 면책사항

제20장 DelveInsight 소개

KSM 26.08.31

Glucagon-like peptide-1 (GLP-1) Agonist Insights and Trends

  • GLP-1 agonists are a type of medication used primarily in the treatment of type 2 diabetes and sometimes for weight management. They work by imitating the action of the natural hormone GLP-1, which helps regulate glucose levels in the blood.
  • The GLP-1 market is rapidly expanding beyond Type 2 diabetes mellitus (T2DM) into obesity and broader metabolic and cardiovascular indications, with Eli Lilly and Novo Nordisk dominating the market and accounting for nearly 94% of market share as of mid-2024.
  • The GLP-1 market is evolving toward a more competitive landscape, driven by oral formulations, dual- and triple-target agonists, and upcoming patent expiries that are expected to enable generic and biosimilar competition across global markets.
  • Eli Lilly's orforglipron (FOUNDAYO), approved in the US in April 2026, became the first oral GLP-1 for chronic weight management without strict food or water restrictions, while Novo Nordisk's Semaglutide (WEGOVY pill) surpassed 1 million prescriptions globally by mid-2026, capturing ~90% of the early oral obesity market.
  • In 2025, Lilly's tirzepatide portfolio delivered strong growth, with MOUNJARO generating USD 22.97 billion and ZEPBOUND USD 13.54 billion, totaling USD 36.51 billion; US revenue increased 53% for MOUNJARO and 174% for ZEPBOUND, driven by strong demand, although lower realized prices partially offset the gains.
  • The American Diabetes Association (ADA) 2026 guidelines position GLP-1 agonist as cardiometabolic therapies beyond glucose control, recommending their use in T2DM patients with ASCVD/high ASCVD risk, heart failure, or Chronic kidney Disease (CKD) regardless of A1C or metformin use. This broadens their addressable market toward cardiovascular, heart failure, and renal risk reduction, while their low hypoglycemia risk supports use in high-risk patients.
  • The GLP-1 landscape has evolved from first-generation agents such as exenatide (BYETTA), liraglutide (VICTOZA), and others to newer therapies including semaglutide (OZEMPIC/WEGOVY/RYBELSUS), the dual GIP/GLP-1 agonist tirzepatide (MOUNJARO/ZEPBOUND), and the oral GLP-1 agonist orforglipron (FOUNDAYO). These advances have expanded treatment options for glycemic control and weight management.
  • The GLP-1 pipeline includes promising candidates such as retatrutide, CagriSema, and survodutide, among others. By leveraging next-generation multi-receptor agonism and complementary metabolic pathways, these candidates have demonstrated greater weight-loss efficacy and broader cardiometabolic benefits than first-generation GLP-1 receptor agonists, positioning them to redefine efficacy benchmarks and expand treatment across increasingly diverse patient populations.

Glucagon-like peptide-1 (GLP-1) Agonist Market Size and Forecast in the 7MM

DelveInsight's 'Glucagon-like peptide-1 (GLP-1) Agonist - Target Population, Competitive Landscape, and Market Metadata-2036' report delivers an in-depth understanding of the GLP-1 agonist, historical and forecasted epidemiology, as well as the GLP-1 agonist market trends in the United States, EU4 (Germany, Spain, Italy, and France), the United Kingdom, and Japan.

The Glucagon-like peptide-1 (GLP-1) agonist market report delivers a comprehensive analysis of the current treatment landscape, including standards of care, clinical practices, and evolving therapeutic algorithms. It evaluates GLP-1 agonist patient burden trends, revenue and market share dynamics, peak patient share and therapy uptake analysis, and provides an in-depth market size assessment, and growth rate projections (Historical & Forecast 2022-2036) across global regions. The report highlights key unmet medical needs in GLP-1 agonist and maps the competitive and clinical landscape to uncover high-value opportunities, providing a clear outlook on future market growth potential.

Key Factors Driving the Glucagon-like peptide-1 (GLP-1) Agonist Market

Growing Identification of GLP-1 Receptor Agonist-Associated Indications

The identification and treatment of metabolic and cardiometabolic conditions amenable to GLP-1 receptor agonists (GLP-1 RAs) are expanding, driven by increasing disease burden, improved clinical understanding, and growing evidence of benefits beyond glycemic control. While type 2 diabetes and obesity remain the core indications, growing evidence and regulatory approvals are expanding opportunities into cardiovascular disease, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction-associated steatohepatitis (MASH).

Rising Opportunities in GLP-1 Receptor Agonists

Increasing clinical validation of GLP-1 receptor agonist, strong efficacy in glycemic control and weight reduction, and expanding indications are creating significant opportunities for the class. The development of oral formulations, dual/multi-receptor agonists, and next-generation incretin therapies is further expected to expand the addressable patient population and strengthen competition within the GLP-1 market.

Glucagon-like peptide-1 (GLP-1) Agonist Understanding and Treatment Algorithm

Glucagon-like peptide-1 (GLP-1) Agonist Overview

GLP-1 is an incretin hormone that plays an important role in regulating glucose metabolism and appetite. GLP-1 receptor agonists mimic the effects of endogenous GLP-1 by enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and increasing satiety. These effects improve glycemic control and reduce food intake and body weight.

Due to their metabolic effects, GLP-1 have become an important therapeutic class for type 2 diabetes and obesity, with expanding applications in conditions such as cardiovascular disease, chronic kidney disease, and obstructive sleep apnea. The development of dual and multi-receptor incretin agonists, along with oral and longer-acting formulations, is further expanding the therapeutic potential and addressable market for GLP-1-based therapies.

Glucagon-like peptide-1 (GLP-1) Agonist Diagnosis

GLP-1 receptor agonists are not associated with a standalone diagnostic condition but are used to manage metabolic disorders based on clinical assessment. Patient eligibility is typically evaluated using measures such as blood glucose levels, HbA1c, body mass index (BMI), and weight-related comorbidities. GLP-1 agonists are primarily used in type 2 diabetes and obesity, with treatment selection increasingly influenced by associated cardiovascular, renal, and metabolic conditions.

Glucagon-like peptide-1 (GLP-1) Agonist Treatment

GLP-1 receptor agonist treatment focuses on activating the GLP-1 receptor to improve glucose regulation, appetite control, and metabolic health. These therapies are primarily used in type 2 diabetes and obesity, with some agents also approved for cardiovascular, renal, and obstructive sleep apnea indications. Most GLP-1 agonist enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and increase satiety. Newer dual and multi-receptor agonists, such as GIP/GLP-1 agonists, are being developed to provide greater improvements in glycemic control and weight reduction.

Glucagon-like peptide-1 (GLP-1) Agonist Unmet Needs

The section "unmet needs of Glucagon-like peptide-1 (GLP-1) Agonist Unmet Needs" outlines the critical gaps between the current state of patient care, diagnosis, and the ideal & effective management of the disease. It highlights the obstacles experienced by patients, clinicians, and researchers and identifies potential solutions for future progress.

1. Improved Tolerability and Adherence

2. Greater and Sustained Weight Reduction

3. More Convenient Administration

4. Broader Cardiometabolic Benefits, and others.....

Comprehensive unmet needs insights in Glucagon-like peptide-1 (GLP-1) Agonist and their strategic implications are provided in the full report.

Glucagon-like peptide-1 (GLP-1) Agonist Epidemiology

Key Findings from Glucagon-like peptide-1 (GLP-1) Agonist Epidemiological Analysis and Forecast

  • Type 2 diabetes mellitus accounts for over 85% of all diabetes cases worldwide. As of 2021, approximately 537 million adults were living with diabetes and About 1.4 million new cases of diabetes are diagnosed in United States every year.
  • As per study conducted in 2024, it is estimated the 12-month discontinuation rate for GLP-1 agonists to be 36.5% overall, with higher rates in patients with obesity alone compared to those with type 2 diabetes. Factors associated with higher discontinuation included younger age, female sex, and higher out-of-pocket costs.
  • According to secondary analysis, use of a once-weekly GLP-1 receptor agonist was independently associated with a 30.5% higher prevalence of increased residual gastric content on preprocedural gastric ultrasonography, a major risk factor for aspiration under anesthesia.

Glucagon-like peptide-1 (GLP-1) Agonist Drug Chapters & Competitive Analysis

The GLP-1 agonist drug chapter provides a detailed, market-focused review of approved therapies and the emerging pipeline. It covers the mechanism of action, clinical trial data, regulatory approvals, patents, collaborations, and strategic partnerships for each therapy, along with their advantages, limitations, and recent developments. This section offers critical insights into the GLP-1 AGONIST treatment landscape, supporting market assessment, competitive analysis, and growth forecasting for the GLP-1 AGONIST therapeutics market.

Approved Therapy for Glucagon-like peptide-1 (GLP-1) Agonist

Orforglipron (FOUNDAYO): Eli Lilly

Orforglipron is a once-daily oral GLP-1 receptor agonist marketed by Eli Lilly under the brand FOUNDAYO and FDA approved in April 2026 for chronic weight management. It is indicated, in combination with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain long-term weight reduction in adults with obesity or adults with overweight with at least one weight-related comorbid condition. Unlike injectable GLP-1 therapies, FOUNDAYO can be taken once daily with or without food and without specific food or water restrictions.

Semaglutide (OZEMPIC/RYBELSUS/WEGOVY): Novo Nordisk

Semaglutide is a GLP-1 receptor agonist marketed by Novo Nordisk under different brand names with distinct FDA-approved indications.

OZEMPIC: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease.

RYBELSUS: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes who are at high risk for these events.

WEGOVY: Indicated, in combination with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain long-term weight reduction in adults and pediatric patients aged 12 years and older with obesity, and in adults with overweight in the presence of at least one weight-related comorbid condition.

WEGOVY is also indicated to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and obesity or overweight, and for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-advanced fibrosis (F2-F3) in adults. Novo Nordisk continues to be GLP-1 volume leader, with 58% market share.

Tirzepatide (MOUNJARO/ZEPBOUND): Eli Lilly

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist marketed by Eli Lilly under different brand names with distinct FDA-approved indications.

MOUNJARO: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

ZEPBOUND: Indicated, in combination with a reduced-calorie diet and increased physical activity, for chronic weight management in adults with an initial BMI of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition, such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea, or cardiovascular disease. ZEPBOUND sales reached USD 4.9 billion in Q2 2026, increasing by USD 1.5 billion from USD 3.4 billion in Q2 2025, representing approximately 44% year-over-year growth, driven by continued increases in US prescription volume and market share.

ZEPBOUND is also indicated for the treatment of moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity, as an adjunct to a reduced-calorie diet and increased physical activity.

Glucagon-like peptide-1 (GLP-1) Agonist Pipeline Analysis

CagriSema: Novo Nordisk

CagriSema, developed by Novo Nordisk, is a once-weekly subcutaneous fixed-dose combination of the long-acting amylin analogue cagrilintide (2.4 mg) and the GLP-1 receptor agonist semaglutide (2.4 mg), currently under investigation for weight management in adults with overweight or obesity.

Survodutide (BI 456906): Boehringer Ingelheim

Survodutide (BI 456906) is a GCGR/GLP1 dual agonist being developed by Boehringer Ingelheim. Both receptors are critical to controlling metabolic functions. The compound leverages the known effects of the natural gut hormone oxyntomodulin, which has been shown to decrease food intake and increase energy expenditure in humans as well as the established effects of GLP1 agonism on both glucose control and body weight. The drug is currently in Phase III.

Glucagon-like peptide-1 (GLP-1) Agonist Key Players, Market Leaders, and Emerging Companies

  • Novo Nordisk
  • Boehringer Ingelheim
  • Eli Lilly
  • AstraZeneca, and others

Glucagon-like peptide-1 (GLP-1) Agonist Key Players Drug Updates

  • In August 2026, Eli Lilly reported positive results from three additional Phase III trials evaluating retatrutide in obesity. With these data, the clinical development package is now complete to support global regulatory submissions across obesity, obstructive sleep apnea, and knee osteoarthritis pain. The company plans to submit a Biologics License Application (BLA) to the FDA in Q1 2027.
  • In June 2026, Boehringer Ingelheim reported detailed Phase III results from the SYNCHRONIZE-1 and SYNCHRONIZE-MASLD trials, demonstrating that survodutide reduced visceral fat by up to 34% and liver fat by up to 63.1% in people with obesity. The results were presented at the ADA 2026 Scientific Sessions.
  • In June 2026, Novo Nordisk reported positive Phase III results from the REIMAGINE 1-3 trials, demonstrating that CagriSema achieved significant reductions in HbA1c and body weight in adults with type 2 diabetes. The findings were presented at the ADA 2026 Scientific Sessions.

Drug Class Insights

Glucagon-like peptide-1 (GLP-1) Agonist Market Outlook

The GLP-1 receptor agonist market is expected to maintain strong growth, supported by the increasing burden of type 2 diabetes mellitus (T2DM) and obesity, expanding use of incretin-based therapies, and growing recognition of their broader metabolic and cardiovascular benefits. The market is increasingly shifting from traditional glucose-lowering applications toward chronic weight management and cardiometabolic risk reduction, with semaglutide and tirzepatide emerging as key growth drivers.

Semaglutide currently holds a strong position because of its established use across diabetes and obesity, availability in both injectable and oral formulations, and broad clinical evidence. Meanwhile, tirzepatide, a dual GIP/GLP-1 receptor agonist, is expected to gain significant market share due to its strong efficacy in glycemic control and weight reduction. In India, tirzepatide is projected to be the fastest-growing product segment, while semaglutide remains the leading product by revenue. GLP-1 therapies offer an effective option for adults with obesity, but WHO emphasizes that medicines alone are insufficient. Obesity requires a multisectoral approach focused on healthier environments, early intervention for high-risk individuals, and lifelong, person-centred care.

The market is also expected to benefit from expanding indications, increasing physician adoption, improved patient awareness, and the development of next-generation incretin therapies. Growing interest in oral formulations could further improve convenience and treatment uptake, while competition between innovative therapies and lower-cost alternatives is likely to influence pricing and market access.

Drug Class/Insights into Leading Emerging and Marketed Therapies in Glucagon-like peptide-1 (GLP-1) Agonist (2022-2036 Forecast)

The current drug class/insights into leading emerging and marketed therapies in GLP-1 receptor agonists are centered on incretin-based metabolic modulation, primarily through activation of the GLP-1 receptor to improve glycemic control, reduce appetite, delay gastric emptying, and promote weight loss.

  • GLP-1 Receptor Agonists: Marketed therapies such as liraglutide, dulaglutide, exenatide, lixisenatide, and semaglutide are approved for the management of type 2 diabetes, with semaglutide and liraglutide also approved for chronic weight management. These therapies have established GLP-1 receptor activation as an effective approach for improving glycemic control and reducing body weight.
  • Dual/Multireceptor Incretin Agonists: Tirzepatide, a dual GIP/GLP-1 receptor agonist, represents a major advancement beyond selective GLP-1 receptor activation. It provides substantial improvements in glycemic control and weight reduction and has become an important competitor to established GLP-1 RAs. Other next-generation multi-agonists are being developed to further enhance weight loss and metabolic benefits.
  • Next-Generation GLP-1 Therapies: The emerging pipeline includes oral GLP-1 receptor agonists, longer-acting formulations, and combination or multi-receptor agonists, with the aim of improving convenience, efficacy, tolerability, and treatment adherence. These approaches are expected to expand the use of incretin therapies beyond diabetes and obesity into broader cardiometabolic conditions.

Glucagon-like peptide-1 (GLP-1) Agonist Drug Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during the forecast period (2026-2036). The analysis covers the GLP-1 AGONIST market's uptake by drugs, patient uptake by therapy, and sales of each drug. The uptake analysis evaluates the potential adoption of GLP-1 therapies based on clinical efficacy, safety and tolerability, treatment persistence, dosing convenience, patient and physician acceptance, pricing and reimbursement, competitive dynamics, and expansion into additional indications. These factors are expected to influence the speed of patient uptake, treatment penetration, and sales growth of individual therapies throughout the forecast period.

Glucagon-like peptide-1 (GLP-1) Agonist Therapies Price Scenario & Trends

Pricing and analogue assessment of GLP-1 agonist therapies highlights evolving price dynamics structures. This section summarizes the cost of approved treatments, the closest and most appropriate analogue selection for emerging therapies, and understanding of how pricing influences market access, adherence, and long-term uptake.

Further details are provided in the final report....

Industry Experts and Physician Views for Glucagon-like peptide-1 (GLP-1) Agonist

To keep up with GLP-1 agonist market trends, we take Key Opinion Leaders (KOLs) and Subject Matter Experts (SMEs) opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts were contacted for insights on GLP-1 agonist emerging therapies, evolving treatment landscape, patient adherence to conventional therapies, therapy switching trends, drug adoption and uptake, accessibility challenges, and epidemiology and real-world prescription patterns in GLP-1 agonist, including MD, PhD, Instructor, Postdoctoral Researcher, Professor, Researcher, and others.

DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 6+ KOLs in the 7MM. Centers such as the University of North Carolina at Chapel Hill, the Berlin Institute of Health at Charite, and the University of Nottingham, etc. were contacted. Their opinion helps understand and validate current and emerging GLP-1 agonist therapies, highlight unmet medical needs, provide epidemiological context, and support strategic decisions for market access, therapy adoption, and pipeline prioritization in GLP-1 agonist.

Qualitative Analysis: SWOT and Conjoint Analysis

We perform qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and conjoint analysis.

In the SWOT analysis of GLP-1 agonist, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint analysis analyzes emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

The team of analysts analyzes promising emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. In efficacy, the trial's primary and secondary outcome measures are evaluated, whereas the therapies' safety is evaluated, wherein the acceptability, tolerability, and adverse events are mainly observed. In addition, the scoring is also based on the route of administration, order of entry, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Scope of the Report:

  • The report covers a segment of key events, an executive summary, a descriptive overview of GLP-1 agonist, explaining its causes, signs and symptoms, pathogenesis, and currently available treatments.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of the diagnosis rate, and disease progression along treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging treatments, along with the elaborate profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the GLP-1 agonist market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM GLP-1 agonist market.

Report Insights

  • GLP-1 Agonist Patient Population Forecast
  • GLP-1 Agonist Therapeutics Market Size
  • GLP-1 Agonist Pipeline Analysis
  • GLP-1 Agonist Market Size and Trends
  • GLP-1 Agonist Market Opportunity (Current and forecasted)

Report Key Strengths

  • Epidemiology-based (Epi-based) Bottom-up Forecasting
  • Artificial Intelligence (AI)-enabled Market Research Report
  • 11-year forecast
  • GLP-1 Agonist Market Outlook (North America, Europe, Asia-Pacific)
  • Patient Burden Trends (by geography)
  • GLP-1 agonist Treatment Addressable Market (TAM)
  • GLP-1 Agonist Competitive Landscape
  • GLP-1 Agonist Major Companies Insights
  • GLP-1 Agonist Price Trends and Analogue Assessment
  • GLP-1 Agonist Therapies Drug Adoption/Uptake
  • GLP-1 Agonist Therapies Peak Patient Share Analysis

Report Assessment

  • GLP-1 Agonist Current Treatment Practices
  • GLP-1 Agonist Unmet Needs
  • GLP-1 Agonist Clinical Development Analysis
  • GLP-1 Agonist Emerging Drugs Product Profiles
  • GLP-1 Agonist Market Attractiveness
  • GLP-1 Agonist Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs:

Market Insights

  • What was the GLP-1 agonist market size, the market size by therapies, market share (%) distribution in 2025, and what would it look like by 2036? What are the contributing factors for this growth?
  • What are the anticipated pricing variations among different geographies for the emerging therapies in the future?
  • What can be the future treatment paradigm of GLP-1 agonist?
  • What are the disease risks, burdens, and unmet needs of GLP-1 agonist? What will be the growth opportunities across the 7MM concerning the patient population with GLP-1 agonist?
  • Who is the major future competitor in the market, and how will the competitors affect their market share?
  • What are the current options for the treatment of GLP-1 agonist? What are the current guidelines for treating GLP-1 agonist in the US, Europe, and Japan?

Reasons to Buy:

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the GLP-1 agonist market.
  • Bottom up forecasting builds from the affected population to product forecasts, delivering a robust, data driven approach ideal for new therapies and novel classes.
  • Insights on patient burden/disease, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the conjoint analysis section to provide visibility around leading classes.
  • To understand KOLs' perspectives on the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights into the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.
  • This Artificial Intelligence (AI) enabled report summarizes and simplifies complex datasets within the report into clear, actionable insights for stakeholders, investors, and healthcare providers, enabling faster, data driven decisions.

Table of Contents

1. Key Insights

2. Report Introduction

3. Executive Summary of Glucagon-like peptide-1 (GLP-1) Agonist

4. Glucagon-like peptide-1 (GLP-1) Agonist Market Overview at a Glance

  • 4.1. Market Share (%) Distribution of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in 2025
  • 4.2. Market Share (%) Distribution of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in 2036
  • 4.3. Market Share (%) Distribution of Glucagon-like peptide-1 (GLP-1) Agonist by Indications in 2025
  • 4.4. Market Share (%) Distribution of Glucagon-like peptide-1 (GLP-1) Agonist by Indications in 2036

5. Epidemiology and Market Methodology of Glucagon-like peptide-1 (GLP-1) Agonist

6. Key Events

  • 6.1. Upcoming Key Catalysts
  • 6.2. Key Conferences And Meetings
  • 6.3. Key Transactions And Collaborations
  • 6.4. News Flows

7. Background and Overview of Glucagon-like peptide-1 (GLP-1) Agonist

  • 7.1. Introduction
  • 7.2. Treatment
  • 7.3. Guidelines

8. Epidemiology and Patient Population of Glucagon-like peptide-1 (GLP-1) Agonist in 7MM

  • 8.1. Key Findings
  • 8.2. Assumptions and Rationale: The 7MM
  • 8.3. Total Cases in Selected Indications for Glucagon-like peptide-1 (GLP-1) Agonist in the 7MM
  • 8.4. Total Eligible Patient Pool in Selected Indications for GLP-1 Agonist in the 7MM
  • 8.5. Total Treated Cases in Selected Indications for GLP-1 Agonist in the 7MM

9. Patient Journey

10. Marketed Therapies

  • 10.1. Marketed Competitive Landscape of Glucagon-like peptide-1 (GLP-1) Agonist
  • 10.2. Semaglutide (OZEMPIC/WEGOVY/RYBELSUS): Novo Nordisk
    • 10.2.1. Drug Description
    • 10.2.2. Regulatory Milestones
    • 10.2.3. Other Developmental Activities
    • 10.2.4. Summary of Pivotal Trials
    • 10.2.5. Clinical Development
      • 10.2.5.1. Clinical Trial Information
    • 10.2.6. Safety and Efficacy
    • 10.2.7. Analyst's Views

11. Emerging Therapies

  • 11.1. Emerging Competitive Landscape of Glucagon-like peptide-1 (GLP-1) Agonist
  • 11.2. CagriSema: Novo Nordisk
    • 11.2.1. Drug Description
    • 11.2.2. Other Developmental Activities
    • 11.2.3. Clinical Development
      • 11.2.3.1. Clinical Trials Information
    • 11.2.4. Analyst's Views
  • 11.3. Survodutide (BI 456906): Boehringer Ingelheim
    • 11.3.1. Drug Description
    • 11.3.2. Other Developmental Activities
    • 11.3.3. Clinical Development
      • 11.3.3.1. Clinical Trials Information
    • 11.3.4. Analyst's Views

12. Glucagon-like peptide-1 (GLP-1) Agonist: 7MM Analysis

  • 12.1. Key Findings
  • 12.2. Market Outlook of Glucagon-like peptide-1 (GLP-1) Agonist
  • 12.3. Key Market Forecast Assumptions
    • 12.3.1. Cost Assumptions
    • 12.3.2. Pricing Trends
    • 12.3.3. Analogue Assessment
    • 12.3.4. Launch Year and Therapy Uptakes
  • 12.4. Conjoint Analysis of Glucagon-like peptide-1 (GLP-1) Agonist
  • 12.5. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist in the 7MM
  • 12.6. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in the 7MM
  • 12.7. The United States
    • 12.7.1. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Indications in the United States
    • 12.7.2. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in the United States
  • 12.8. EU4 and the UK
    • 12.8.1. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Indications in EU4 and the UK
    • 12.8.2. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in EU4 and the UK
  • 12.9. Japan
    • 12.9.1. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Indications in Japan
    • 12.9.2. Total Market Size of Glucagon-like peptide-1 (GLP-1) Agonist by Therapies in Japan

13. Unmet Needs of Glucagon-like peptide-1 (GLP-1) Agonist

14. SWOT Analysis of Glucagon-like peptide-1 (GLP-1) Agonist

15. KOL Views of Glucagon-like peptide-1 (GLP-1) Agonist

16. Market Access and Reimbursement

  • 16.1. The United States
  • 16.2. EU4 and the UK
    • 16.2.1. Germany
    • 16.2.2. France
    • 16.2.3. Italy
    • 16.2.4. Spain
    • 16.2.5. United Kingdom
  • 16.3. Japan
  • 16.4. Summary and comparison of Market Access and Pricing Policy Developments in 2025
  • 16.5. Market Access and Reimbursement of Glucagon-like peptide-1 (GLP-1) Agonist Therapies

17. Appendix

  • 17.1. Bibliography
  • 17.2. Report Methodology

18. DelveInsight Capabilities

19. Disclaimer

20. About DelveInsight

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